Fact Checked
Medically Reviewed by Overview
Apoaequorin is a protein that is extracted from a type of glowing jellyfish. When apoaequorin is exposed to calcium, protein and calcium bind, creating a bluish light. Therefore, scientists have used apoaequorin to study the properties of calcium.
The synthetic version is added to nootropic supplements because it’s considered to improve memory and mental functioning. In addition, it can enhance the quality of your sleep.
One of the top companies that make apoaequorin is ‘Quincy Bioscience’ and the product is called Prevagen.
Apoaequorin Review – Health Insiders Images
Apoaequorin Pros & Cons
- Apoaequorin may improve the quality of your sleep and can help your memory.
- There’s not enough evidence to determine correct dosing yet.
- It may lead to mild side effects like nausea, dizziness, or headaches.
- Apoaequorin could occasionally lead to heart or nervous system complications.
- There is little evidence that this product will improve mental function
- Other side effects could a seizures or strokes
How Does It Work | The Science Behind Apoaequorin
Researchers believe that calcium regulation in the brain may play a role in preventing mental decline and improve memory.
There are other studies that indicate that in fact, Apoaequorin is digested in the stomach and never ever gets to the brain.
According to the American Pharmacists Association, apoaequorin most likely will not be absorbed, instead, it will separate into individual proteins called amino acids. Once separated into amino acids, the body will use them the same as the amino acids from food sources.
In 2017, the Federal Trade Commission (FTC) filed a complaint with the company “Quincy Bioscience” because there was reason the company may have false advertising claims.
Currently, there is insufficient evidence to recommend apoaequorin for amyotrophic lateral sclerosis (ALS, Lou Gehrg’s disease), to increase mental function and other conditions.
A company-sponsored study called the Madison Memory Study tested the product for its effectiveness. The study had 218 participants between the ages of 40-91 years who had memory problems. The results of the study showed improvements in memory among participants.
Although, the research study report had many issues and non-standardized assessment techniques were used.
Apoaequorin Ingredients – What to Look For?
This is not a supplement, it’s an individual ingredient. This substance is derived from a jellyfish. Apoaequorin is a protein that’s found inside the Aequorea Victoria species of jellyfish.
Note: In 2012, the Food and Drug Administration (FDA) labeled this product as a drug.
Apoaequorin Alternativess
| Brand | Price | Active Ingredients |
|---|---|---|
| Apoaequorin | $39.95 | apoaequorin |
| Relief Factor Calm | $21.95 | Passionflower, Phosphatidylserine |
| Neuriva | $44.99 | Coffee Fruit Extract, Phosphatidylserine |
| Alpha Brain | $34.95-$79.95 | Bacopa, Toothed Clubmoss, Cat’s Claw, L-Tyrosine, L-Theanine, Oat Straw, L-Leucine, Phosphatidylserine |
| Cerebra | $49.95 | Citicoline, Bacopa Monnieri, Phosphatidylserine |
| Zenith Brain C-13 | $39 | Huperzine A, DMAE, Rosemary leaf, rhodiola root, turmeric, gingko leaf, |
| Neuronol | $52.95 | Caffeine, L-Glutamine, Taurine, Bacopa Monnieri, Gingko Biloba, Acetyl L-Carnitine, DMAE |
| Dynamic Brain | $43.95 | Huperzine A, Bacopa Monnieri, Choline, Phosphatidylserine, Grape Seed Extract, Cinnamon Bark, Olive Leaf, L-Tyrosine |
The price of the apoaequorin will depend on the brand. In this case, it’s relatively inexpensive, about mid-range in the market.
Advertisement
*All individuals are unique. Your results can and will vary.
None of the other brain supplements include the ingredient apoaequorin, which is quite telling. It’s obviously not considered all that great a brain health substance.
Is It Safe? – Warnings & Complaints
When ingested orally, this ingredient is fairly safe. It has only been studied for safety for a period of 90 days. Further research is needed to study safety for long-term use.
NOTE: You may experience mild side effects like headaches or nausea. Occasionally customers have reported anxiety, memory lapses, or sleeping problems. In very rare cases there are heart or nervous system complications.
Apoaequorin Customer Reviews & Results
Overall, reviews about this substance have been more negative than positive. The consensus seems to be that even after months of use, it has very little effect on memory or general cognitive functioning for the majority of customers.
Apoaequorin: Packages, Deals, Prices & Where to Buy It
This is an ingredient, not a product in and of itself. You’d have to look for supplements that include apoaequorin and compare prices.
Is There Anything Else You Should Know About Apoaequorin?
Taking a substance or supplement for cognitive enhancement may help improve your memory and mental functioning. This could be especially helpful if you’re experiencing some kind of mental decline.
However, there are also some natural things you can do to improve your brain health.
- Eat nutrient-rich foods with lots of vitamins and minerals. Eat more fruits and vegetables, adequate-protein, and reduce your fat and carbohydrate intake.
- Try to keep in excellent physical condition. Exercise for at least 150 minutes per week or 75 minutes per week of vigorous activity.
- Keep your brain active by reading, doing puzzles, and working on problem-solving tasks.
- Make sure you get an adequate amount of quality sleep every night.
Read Next – Cognifen and Genbrain
Final Verdict
The only research available is from small company-sponsored trials that do not meet scientific standards. More research is needed to determine the effectiveness of this product.
In reality, looking at reviews of products, it doesn’t seem to work well. There are more negative than positive reviews.
Before you begin taking any supplement like Natrol Cognium, Reviva Brain or Limitless NZT-48, make an appointment with your doctor to discuss whether it’s medically suitable for you.
Apoaequorin – Frequently Asked Questions
Q: How to Use Apoaequorin?
A: Apoaequorin is included in some nootropic supplements. As far as the dosing is concerned, there hasn’t been enough scientific research done yet on this substance to know exactly what the dosing should be.
Q: Does Apoaequorin Have Any Side Effects?
A: This substance may cause mild side effects such as nausea, dizziness, or migraine headache. Less commonly, users have experienced anxiety, memory issues, and difficulty sleeping. In a very small number of cases, this substance has led to heart or nervous system problems.
Advertisement
*All individuals are unique. Your results can and will vary.
Q: Can I Take Apoaequorin If I Have A Health Condition?
S: There are no specific health conditions that preclude taking this substance, except being pregnant or breastfeeding.
Q: Does Apoaequorin Work?
A: It may have some limited benefit, but it doesn’t appear to work very well. Most users mentioned that even after months of use, there was no difference in their thinking or memory skills.
Q: What Is Apoaequorin Moneyback Guarantee, Return & Refund Policy
A: This is an ingredient, not a supplement, but it is included in many nootropic supplements. You’d have to find some of these supplements and compare prices and return policies.
SOURCES
Health Insiders relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.
[1] Apoaequorin: Uses, Side Effects, Interactions, Dosage, and Warning | WebMD https://www.webmd.com/vitamins/ai/ingredientmono-1486/apoaequorin
[2] Apoaequorin | Alzheimer's Drug Discovery Foundation https://www.alzdiscovery.org/uploads/addf_access/addf-apoaequorin-full-report.pdf
Strong Evidence
Moderate Evidence
Yes
Katie Whetstone, RD
See
Our Editorial Process
Meet
Our Review Board
This article changed my life!
This article was informative.
I have a medical question.
Ask a Question
This article contains incorrect information.
This article doesn’t have the information I’m looking for.
Upset my stomach somewhat. Stopped taking it.
I’m not really sure how much it does. It upset my stomach somewhat. I was willing to take it just in case. But the cost is prohibitive. I gave it 2 stars because I couldn’t bring myself to totally trash someone’s product and I stopped taking it.
May cause side effects!
After taking these products for about 30 days, I had a grand mal seizure, while driving. I’ve never had a seizure or any neurological disorder before in my life. I am a fit healthy 50 yr old female. In doing research, I found that side effects found in test studies included seizures and strokes. Because this product is over-the-counter, the manufacturer apparently does not have to report this information.
I would not try this again.....
I have taken nootropics since the beginning. I am to the point to find the best or my money. The ones that are good twice the price. This one had gotten great reviews. Thought I would give it a try. It did really nothing for me. Just not a jerk to put a one-star. Definitely save your money. I would not try this again.