Most Popular Weight Loss Supplements & Diet Pills 2023 [Expert Reviewed]

*Note– Each product we feature has been independently selected and reviewed by our editorial team. If you buy something through a link on this page, we may earn a small commission. How this works.

Weight Loss Pills – Overview

Weight loss pills, be they prescription or over-the-counter, use a variety of mechanisms for burning fat and losing weight. Some diet pills, speed up metabolism using certain ingredients, like caffeine. This initiates the fat-burning process of thermogenesis.

Other diet pills suppress hunger, so you don’t overeat, or so you don’t crave carbohydrates. There are pills specifically geared towards those who are following a keto diet. They include extra ketones, which keep the body in a fat-burning state.

Even with some of the best weight loss supplements and best diet pills readily found online or in stores, it can be difficult to choose the appropriate one. Does confusion arise with the questions like What are the best diet pills for women? What supplements help with weight loss? Which weight loss supplements actually work? What are the best natural weight loss supplements?

No weight loss pills work to result in ‘miraculous’ weight loss. A good diet and exercise will always be part of the equation, but there are some diet pills that are known to be better than others, so it’s important to look at all of the factors when choosing the best one for you.

What are our Ideal Ingredients for Choosing The Best Supplements For Weight Loss?

• Garcinia Cambogia Extract – Weight Loss Supplements with Garcinia Cambogia has a lot of hydroxycitric acids, which can speed up the metabolism and also curb hunger. There’s only minimal research showing that this substance helps with weight loss.
• Caffeine – It speeds up the metabolism and so it leads to a lot of fat burning. It also gives you extra energy, which helps you be more active. The Mayoclinic says that the amount of weight you can lose from caffeine is limited.
• Green Coffee Bean Extract – This has a substance called chlorogenic acid, which burns fat. It also has other health benefits.
• Glucomannan – This is a dietary fiber is often used in foods because it’s an emulsifier. It has been sold as a weight-loss substance for 10 years, although there’s very little evidence to prove this.
• Green Tea Extract – It initiates the process of thermogenesis, which does lead to weight loss. It has quite a bit of caffeine, which quickens the metabolism.
• Conjugated Linoleic Acid (CLA) – A collection of chemicals that make up the fatty acid linoleic acid. Research indicated that ingesting CLA does lead to a moderate weight and fat loss.
• Forskolin – It’s a weight-loss substance that many people think can release fatty acids, burning fat and making weight-loss more rapid. It may also prevent new fat from forming quickly on the body. The evidence that Forskolin is an effective weight loss substance is not very strong.

How Do We Rank the ‘Best Weight Loss Pills’?

In order to rank each weight loss pill, we use a rigorous process where we research every element of both company and the pill. We look at the reputation of the company, and how reliable and effective its products are in general.

We also look at their certifications in the industry, which is another indicator of how reputable the company is.

The ingredients are a key factor in deciding what the best diet pills are. We look at the scientific research behind each substance, and whether data backs up its weight-loss potential. Naturally, we also look carefully at customer reviews.

Here are the weight loss pills that really work:

Best Weight Loss Supplements and Diet Pills of 2023

PhenQ

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*All the prices listed here are as they appear on their websites and are subject to change.

Quick Facts & Specs

PhenQ

PhenQ is a fat-burning weight-loss supplement that claims to combine the benefits of other weight-loss supplements to provide you with an all-in-one, stress-free weight-loss experience.

• Form:Capsule
• Type:Supplement
• Benefit:Effortless weight loss experience, easy to use formula
• Brand:PhenQ
• Active Ingredients:α-Lacys Reset, Nopal, Caffeine, Capsimax Powder, Chromium Picolinate, L-Carnitine Furmarate
• Price:$69.95*

PhenQ Manufacturer Claims

• It targets 5 different elements of weight loss.
• PhenQ is one of the effective fat burning pills.
• It blocks fat production.
• The supplement curbs your appetite.

PhenQ Dosage

One tablet twice a day; one with breakfast and the second with lunch.

Gundry MD MCT Wellness

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*All the prices listed here are as they appear on their websites and are subject to change.

Quick Facts & Specs

MCT Wellness

Gundry MD MCT Wellness is formulated with a uniquely potent blend of caprylic acid that supports a healthy metabolism, works as an energy booster, and promotes clear mind sharpness.

• Form:Powder
• Type:Supplement
• Benefit:Boosts metabolism & energy levels, enhances fat-burning process, gives mind sharpeness
• Brand:Gundry MD
• Active Ingredients:GoMCT C8, Malic Acid, MitoHeal, Citric Acid, Silica, Monk Fruit Extract and Red Grape Extract
• Price:$49.95*

MCT Wellness Manufacturer Claims

• It can increase your energy.
• It may improve your mood.
• This is a high-quality product.

MCT Wellness Dosage

One scoop (7.8 g) per day with 10 oz of water.

KetoCharge

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*All the prices listed here are as they appear on their websites and are subject to change.

Quick Facts & Specs

KetoCharge

KetoCharge is an organic dietary supplement designed for the users following keto diet. It contains exogenous ketones that promote fat burning and rapid weight loss, provide added energy as well as health and immunity benefits.

• Form:Capsules
• Type:Keto Weight Loss Supplement
• Benefit:Supports weight loss and fat burning, keeps you in ketosis, boosts energy
• Brand:Keto Charge
• Active Ingredients:Betahydroxybutyrate with Magnesium, Sodium, and Calcium
• Price:$59.99*

KetoCharge Manufacturer Claims

• It includes healthy, potent weight loss ingredients.
• The product is safe and effective.
• Designed for the ketosis diet followers.

KetoCharge Dosage

Four capsules each day with an 8oz glass of water.

Nucific Bio X4

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*All the prices listed here are as they appear on their websites and are subject to change.

Quick Facts & Specs

Bio X4

Nucific Bio-X4 is a probiotic-based dietary supplement that claims to help with hunger management, metabolism, and digestion.

• Form:Capsule
• Type:Supplement
• Benefit:Enhances gut health, supports smoother digestion, promotes weight loss
• Brand:Nucific
• Active Ingredients:Amylase, Bromelain, Lipase, Green Tea Extract, Caralluma Fimbriata, Probiotic Blend
• Price:$49*

Nucific Bio X4 Manufacturer Claims

• The supplement improves digestion.
• It helps you lose weight.
• This product curbs your hunger.

Nucific Bio X4 Dosage

One capsule with each meal – breakfast, lunch and dinner.

Active PK

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*All the prices listed here are as they appear on their websites and are subject to change.

Quick Facts & Specs

Active PK

Active PK is a fat-burning supplement that works by increasing AMPK levels in the body. When AMPK levels are high, fat burning increases, resulting in increased energy and weight reduction.

• Form:Capsules
• Type:Supplement
• Benefit:Helps regulate blood sugar and lower cholesterol levels, improves metabolic rate
• Brand:LCR Health
• Active Ingredients:Berberine, Quercetin, Gynostemme Pentaphyllum
• Price:$46.95*

Active PK Manufacturer Claims

• Active PK can fight fatigue, giving you energy.
• It promotes AMPK activation, converting nutrients to energy.
• It can break down fat in the body.
• This supplement includes no stimulants like caffeine.

Active PK Dosage

Two capsules with a glass of water, either with food or on an empty stomach.

Phen24

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*All the prices listed here are as they appear on their websites and are subject to change.

Quick Facts & Specs

Phen24

Phen24 is 24/7 fat-burning system which speeds up metabolism, leading to fat and calorie burning promoting the healthy weight loss and gives you energy during the day, and providing a much better quality of sleep at night.

• Form:Capsules
• Type:Supplement
• Benefit:Provides added energy, promotes weight loss and fat loss, enhances immune health
• Brand:Phen24
• Active Ingredients:Cayenne Powder, Calcium D- Pantothenate, Caffeine, L-Phenylalanine
• Price:$84.99*

Phen24 Manufacturer Claims

• The supplement can speed up the metabolism and supports enhanced energy.
• It is suitable for vegetarians.
• The product can suppress the appetite.

Phen24 Dosage

Phen24 Day – One capsule, each morning with breakfast.

Phen24 Night – Two capsules, 15 minutes before evening meal with 1 to 2 glasses of water.

Dad Bod Destroyer Stack

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*All the prices listed here are as they appear on their websites and are subject to change.

Quick Facts & Specs

Dad Bod Destroyer Stack

Dad Bod Destroyer Stack is a set of 3 organic products for men which promote weight loss, muscle building, improved immune functioning, and better sleep quality.

• Form:Capsules and Powder
• Type:Dietary Supplement
• Benefit:Suppresses hunger, speeds up fat loss, promotes weight loss, and building muscle mass and strength
• Brand:Alpha Lion
• Active Ingredients:Ashwagandha, L-Taurine, Garcinia Cambogia, Panax Ginseng, Caffeine Anhydrous, Melatoni
• Price:$147 for set of 3 products*

Dad Bod Destroyer Stack Manufacturer Claims

• It helps promoting weight loss.
• Boosts mood and energy.
• It promotes building muscle mass and strength.

Dad Bod Destroyer Stack Dosage

Superhuman Burn: One scoop; 20-30 minutes before training session.

Cravings Killer: One capsule 30 minutes prior with each meal – breakfast and lunch.

Night Burn: Two capsules 45 minutes prior the bed-time.

PhenGold

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*All the prices listed here are as they appear on their websites and are subject to change.

Quick Facts & Specs

PhenGold

PhenGold weight-loss supplement is made from all-natural ingredients, designed to kick-start the body’s metabolic processes.

• Form:Capsule
• Type:Supplement
• Benefit:Supports thermogenesis for calorie reduction, improves mental and physical performance
• Brand:PhenGold
• Active Ingredients:L-Tyrosine, L-Theanine, Vitamin B6, Green Tea, Rhodiola SP
• Price:$59.95*

PhenGold Manufacturer Claims

• The product will give you energy which helps you be more active.
• It triggers your body’s natural weight-loss abilities.
• It offers long-term weight loss support benefits

PhenGold Dosage

Three capsules 20 minutes before breakfast every morning (ideally before a workout).

TrimTone

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*All the prices listed here are as they appear on their websites and are subject to change.

Quick Facts & Specs

TrimTone

Trimtone is formulated with all-natural ingredients designed to help support your weight loss so you can achieve your best body. It stimulates thermogenesis – the conversion of stored fat into energy – and speeds up the metabolism.

• Form:Capsule
• Type:Supplement
• Benefit:Acts as an instant dose of energy and alertness
• Brand:TrimTone
• Active Ingredients:Green Coffee, Grains of Paradise, Caffeine, Glucomannan
• Price:$49.99*

TrimTone Manufacturer Claims

• It will help you meet your weight-loss goals.
• This product will enhance your mood.
• Reduces calorie absorption.

TrimTone Dosage

One capsule each morning with 8oz of water 30mins before your breakfast.

Exipure

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*All the prices listed here are as they appear on their websites and are subject to change.

Quick Facts & Specs

Exipure

Exipure weight loss supplement is uniquely designed that not only helps tp lose weight but also keep it off, as well as improve your overall health.

• Form:Capsule
• Type:Supplement
• Benefit:Improves cholesterol levels, supports blood glucose management and weight loss
• Brand:Exipure
• Active Ingredients:Perilla Extract, Kudzu extract, Oleuropein, Holy Basil Extract, Amur Cork bark, Propolis Extract
• Price:$59*

Exipure Manufacturer Claims

• It only uses natural ingredients.
• This supplement is safe and effective.
• It doesn’t contain stimulants.

Exipure Dosage

One capsule daily with a large glass of water.

LeanBean

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*All the prices listed here are as they appear on their websites and are subject to change.

Quick Facts & Specs

LeanBean

LeanBean fat burner for women is the number 1 supplement of female athletes.

• Form:Pills
• Type:Supplement
• Benefit:Specifically formulated for women with an active lifestyle, consists of ingredients with proven fitness and weight loss benefits
• Brand:LeanBean
• Active Ingredients:Chilone, Konjac Fibre, Glucomannan, Chromium Picolinate, Vitamins B6, and B12, Chloride, Zinc, Green Coffee
• Price:$59*

LeanBean Dosage

Six capsules with 8oz of water per day; 30 minutes before breakfast, lunch and dinner.

Lipozene

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*All the prices listed here are as they appear on their websites and are subject to change.

Quick Facts & Specs

Lipozene

Lipozene is a fiber-containing supplement hailed for its effectiveness for weight loss.

• Form:Capsule
• Type:Supplement
• Benefit:Helps reduce weight, supports healthy cholestrol and blood sugar levels
• Brand:Lipozene
• Active Ingredients:Amorphophallus Konjac (from Konjac root)

Lipozene Dosage

Two capsules 30 minutes before meals and up to three times per day with 8oz of water.

Hydroxycut

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*All the prices listed here are as they appear on their websites and are subject to change.

Quick Facts & Specs

Hydroxycut

Hydroxycut weight loss supplement helps to boost energy, enhance mental focus, and may help to reduce weight and reduce appetite.

• Form:Capsule
• Type:Supplement
• Benefit:Helps regulate blood sugar levels, gives effective weight loss results
• Brand:Hydroxycut
• Active Ingredients:Robusta coffee extract (as C. canephora robusta), Caffeine

Hydroxycut Dosage

One serving of Hydroxycut 30 to 60 minutes before the two largest meals.

Instant Knockout Cut

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*All the prices listed here are as they appear on their websites and are subject to change.

Quick Facts & Specs

Instant Knockout Cut

Instant Knockout Cut fat burner utilizes the latest advances in natural weight loss understanding to produce a supplement that is in the corner of professional athletes around the world.

• Form:Capsule
• Type:Supplement
• Benefit:Reduces appetite and food cravings, fuels energy levels
• Brand:Instant Knockout
• Active Ingredients:Green Tea Extract, Glucomannan, Caffeine, L-Theanine, Black Pepper Extract
• Price:$65*

Instant Knockout Cut Dosage

One capsule with a glass of water four times a day.

PrimeShred

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*All the prices listed here are as they appear on their websites and are subject to change.

Quick Facts & Specs

PrimeShred

PrimeShred is a high-potency fat burner scientifically formulated to deliver extreme fat burning and accelerated weight loss.

• Form:Capsule
• Type:Supplement
• Benefit:Supports boost in energy, mood, and mental focus, targets the stored body fat
• Brand:PrimeShred
• Active Ingredients:Green Coffee, Green Tea Extract, Caffeine, L-Tyrosine
• Price:$99.99* + Shipping

PrimeShred Dosage

Three PrimeShred capsules approximately 20 minutes before breakfast.

Note: For getting the best result, supplements should be taken with caution and under the supervision of a physician. Please consult your doctor before considering any supplements to evaluate the pros and cons, as well as any potential side effects, especially if you have a pre-existing health problem.

Benefits of Diet Pills

• Weight-loss ingredients can lead to at least moderate weight loss and fat burning, as reported in some studies.
• They give you energy which can help you to be more active.
• The pills speed up the metabolism, which leads to weight loss.
• According to the scientific research, these weight loss ingredients also have other healthy properties.
• Many of them are rich in antioxidants.

Side Effects of Diet Pills

According to the National Institute of Health, prescription weight loss medications can lead to different side effects depending on the specific pill.

These range from mild effects like diarrhea and stomach pain to more severe consequences like liver problems in rare cases.

Research on Conjugated Linoleic Acid has indicated that it does lead to weight loss, but that there are mild to moderate potential side effects associated with its consumption. These include oxidative stress, insulin resistance, and gastrointestinal irritation.

Green Coffee and Tea are high in caffeine, which can make you jittery or nervous and give you a lot of extra energy.

Some people are intolerant of ingesting caffeine. Caffeine is also a diuretic which will send you running to the bathroom a few more times than usual. However, this has no negative effects.

One research study reported mild side effects associated with taking Forskolin which included stomach upset and diarrhea.

Best Weight Loss Pills and Supplements – Frequently Asked Questions

Do Weight Loss Pills Really Work?

There are two types of diet pills – prescription, and over-the-counter supplements. There are some in each category that has some degree of effectiveness, depending on the quality and ingredients.

According to the Mayo Clinic, “All prescription weight-loss drugs approved for long-term use produce significant weight loss compared with placebo.” Supplements have anecdotal reports of effectiveness.

However, weight loss pills are not a magic solution. The focus of weight loss should always be changing your eating habits and exercising. These best diet pills are only a tool to speed up or enhance the effects of regular weight loss.

What Should You Look For When Buying Diet Pills?

It’s really important to do your research when choosing a diet pill. There are a number of factors to consider. You want the best quality ingredients available, so check the back of the bottle against the list we’ve provided you.

In addition, do your own independent research on the ingredients and on the reliability of the manufacturer.

If you’re looking for the non-prescribed, best all-natural diet pills, then you need to check that the ingredients really are all-natural. Have a look at the inactive ingredients to see that there aren’t any chemicals, dyes, or artificial flavors. The more organic, the better.

Naturally, the price is a concern, but you should also have a good look at the company’s money-back guarantee. Choose a product with at least 60 days. A 30-day guarantee isn’t long enough for you to try out the pills, see if they work, and send the product back before the end of the period to get your refund.

For any diet pill you’re considering, look at the warnings to see if there are any safety concerns. There may be concerns listed for people with specific issues or illnesses or just general safety concerns. Another way to find out about safety issues is to research the product to see what’s been said about it.

Finally, look into the scientific research both about the products that interest you – if there is any – and about the ingredients included. It’s important that you be aware of exactly what you’re putting in your body.

Who Should Buy Weight Loss Pills?

Weight loss pills are intended specifically for people who have weight-related health issues. It’s also for individuals who are at risk of having health problems due to being overweight or obese.

Someone is defined as overweight if they have a BMI (Body Mass Index) of more than 25. Obese is defined as having a BMI of over 30.

This is a decision that you must discuss with your doctor before beginning a regimen of diet pills. The physician will consider your medical history, the medications you are currently taking, and the benefits of weight loss to your overall health and lifestyle.

Not every person who is overweight or obese should be taking diet pills or any weight loss products. Your doctor may decide that a special diet or other lifestyle change is more appropriate for you, or that you may succeed better at.

What is The Best Pill To Lose Belly Fat?

There are no healthy best over the counter weight loss pills that will get rid of body fat. Green tea extract contains an anti-oxidant called EGCG which may help increase fat utilization, although you should not expect any miraculous results from this.

Which Weight Loss Pills Are Safe?

There’s no guarantee of the safety of any of these diet pills, including those which are prescription. This is because medications behave differently depending on the individual.

Both prescription and over-the-counter supplements have the potential for side effects or allergic reactions. This is yet another reason to consult with your physician before taking weight loss pills.

What Type of Weight Loss Supplements and Diet Pills Are The Best?

Checking our “best weight loss supplements” product reviews. Another way is to know what they should offer or what ingredients they should avoid. However, in order to make rather more important choices, you should first research about the categories of over-the-counter diet pills and supplements:

• Appetite Suppressants
• Fat Blockers
• Carb Blockers
• Thermogenic Fat Burners

Can Children or Teenagers Take Weight Loss Pills?

A: Weight loss pills are not intended for children or teenagers. Most prescription diet pills are approved for adult use only, and this is also true of over-the-counter diet supplements.

Best Supplements For Weight Loss 2023: Summarization

Here’s a quick recap of the best weight loss pills that actually work.*

• PhenQ – Best weight loss pill overall
• MCT Wellness – Best dietary supplement for weight loss
• KetoCharge – Best keto weight loss pill
• Bio X4 – Best weight loss supplement
• Active PK – Best weight loss supplement and the strongest AMPK Activator
• Phen24 – Best weight loss pills and unique day and night formula
• Dad Bod Destroyer Stack – Best supplements for weight loss and muscle gain
• PhenGold – Best appetite suppressant weight loss pill
• TrimTone – Best fat burners pills for women
• Exipure – Best natural supplements for weight loss
• LeanBean – Best diet pills for women
• Lipozene – Best over the counter weight loss pills
• Hydroxycut – Best fat burning supplement
• Instant Knockout Cut – Best fat burners for professional athletes
• PrimeShred – Best weight loss pills for men

Best Supplements For Weight Loss – The Conclusion

The bottom line is without proper diet and exercise none of these diet pills and weight loss pills work. The bottles make a variety of claims, but they will not result in miraculous weight loss. We reviewed the most popular diet pills and fat burning pills to lose weight out there for the year and some information about each one.

Hopefully, this will help you decide both if a diet pill is right for you, and which one you may choose for your own weight loss program.

Remember to do your own personal research on the ingredients and on the products. It’s important to learn as much as you can about any product that you’ll be putting in your body.

In addition, it’s essential that you see your doctor before you start taking any diet pill or fat burning pill. Not everyone is medically suited to be taking this type of medication.

Ana Reisdorf, MS, RD

Ana Reisdorf has 12 years of experience as a Registered Dietitian. She has a passion for creating incredible health and nutrition conte... [Read Full Bio]

Written by

Health Insiders Team

The Health Insiders Team takes pride in bringing you the latest in nutritional research, skincare, healthy living, and wellness hacks. Together our researchers... [Read Full Bio]

Reviewed by Ana Reisdorf, MS, RD