18 Best OTC Sleep Aids Supplements of 2025 – Expert Reviewed

Trouble sleeping? Here is the list of the best OTC sleep aids, a considered option to help treat insomnia and other sleep problems. If you think you should take sleep supplements, here’s what you need to know.

Disclosure: Every product is independently selected by our editors. Things you buy through our links may earn Health Insiders a commission. Learn more about our review process here.

12 Sources

Health Insiders relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

[1] Prescription Sleep Aid Use Among Adults: United States, 2005–2010: What they are and what they do: https://www.cdc.gov/nchs/products/databriefs/db127.htm

[2] Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063773

[3] GABA and l-theanine mixture decreases sleep latency and improves NREM sleep: https://pubmed.ncbi.nlm.nih.gov/30707852/

[4] Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review: https://pmc.ncbi.nlm.nih.gov/articles/PMC7527439/

[5] Chamomile: A herbal medicine of the past with bright future: https://pmc.ncbi.nlm.nih.gov/articles/PMC2995283/

[6] Analysis, Nutrition, and Health Benefits of Tryptophan: https://pubmed.ncbi.nlm.nih.gov/30275700/

[7] The effects of aromatherapy essential oil inhalation on stress, sleep quality and immunity in healthy adults: Randomized controlled trial: https://www.sciencedirect.com/science/article/abs/pii/S1876382017300951

[8] Mood and sleep: https://www.betterhealth.vic.gov.au/health/healthyliving/Mood-and-sleep

[9] Sleep Problems and Menopause: What Can I Do?: https://www.nia.nih.gov/health/menopause/sleep-problems-and-menopause-what-can-i-do

[10] Effects of moderate aerobic exercise training on chronic primary insomnia: https://www.sciencedirect.com/science/article/abs/pii/S1389945711002553

[11] Over-the-counter sleep aid medications and insomnia: https://www.semanticscholar.org/paper/Over-the-counter-sleep-aid-medications-and-insomnia-Randall-Roehrs/0e73c176c50f7c791bdf9047c7d4a04d45b6d85e

[12] Natural Sleep Aids: Home Remedies to Help You Sleep: https://www.hopkinsmedicine.org/health/wellness-and-prevention/natural-sleep-aids-home-remedies-to-help-you-sleep

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HealthInsiders Team
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Health Insiders Team

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