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Nucific Bio X4 Review – Is This 4-in-1 Weight Management Probiotic Supplement Safe?

Nucific Bio X4 Review – Is This 4-in-1 Weight Management Probiotic Supplement Safe?

Bio-X4 is a probiotic-based nutritional supplement that claims to control appetite, boost metabolism and improves digestive health.

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About Bio X4 Probiotics

Bio X4 is a weight loss aid that comes in capsule form. The purpose of this supplement is to curb cravings, improve digestion, and increase metabolism to promote weight loss. Bio X4 by Nucific, which was founded by Dr. Amy Lee (Bariatric Physician) and is based out of California. The company’s mission is to utilize science and offer products that help your body function at its optimal level.

Nucific sells a variety of supplements and has been accredited by the Better Business Bureau since 2016. The company currently holds an A+ rating, despite customer complaints of overcharging and shipping errors.

In this review of Bio X4, we’ll analyze all aspects of the Nucific Bio X4 probiotic supplement to help you make the best decision for your health, answering common questions like:

  • Are there any Bio X4 side effects?
  • What do Nucific reviews and complaints say?
  • Is Bio X4 safe?
  • Does Bio X4 really work?
  • Is the Bio X4 supplement worth it?

Is Dr. Amy Lee a real doctor?

Amy Lee, MD is a Internal Medicine Specialist in Riverside, CA and has over 47 years of experience in the medical field. She graduated from Taipei Medical University medical school in 1973. Her profile can be seen on the websites like Healthgrades, US News, Lindora, Seattle Children’s, UW Medicine – Seattle, and MedStar Health.

Bio X4

Nucific Bio X4 Review – Health Insiders Images

You can BUY it directly from the manufacturer’s Official Website

Who is the Manufacturer?

Bio X4 is a product from one of the reputable health and wellness companies known as Nucific. It is known for its high quality and healthy products like Nucific Slimming Chocolates, Probiotic Complex, Deep Cell Activator, Carb-C6, Prebio Cleanse, Antarctic Krill Oil, MoroSlim.

Bio X4 Ingredients – The Breakdown

The ingredients in Bio X4 are made up of 4 proprietary blends and in parentheses are amounts of each main ingredient in 1 capsule.

We examined the scientific evidence behind Bio X4 ingredients to see if these claims hold up.

  • Probiotic Blend (4 Billion CFU): mixture of Lactobacillus and Bifidobacterium strains. Bio X4 probiotics are most commonly used to treat gastrointestinal conditions, but specific strains may offer various types of additional health benefits. For example, Lactobacillus acidophilus may reduce the severity of lung infections in children and number of eczema breakouts in infants and Bifidobacterium lactis may boost your immune system.
  • Digestive Enzyme Blend (43mg): combination of amylase, bromelain, and lipase. Amylase and lipase are enzymes in the body – amylase breaks down carbohydrates and lipase breaks down fat for easier digestion. Bromelain is an enzyme mixture in pineapple that is commonly taken for sinusitis and may show promise in treating other inflammatory-related conditions. In regards to gut health, bromelain may help an upset stomach and reduce diarrhea, but according to the National Institute of Health, may or may not be helpful in digestion.
  • Weight Management Blend (100mg): green tea extract that is 50% epigallocatechin gallate (EGCG), a highly potent antioxidant naturally found in green tea. Green tea can boost metabolism to promote weight loss, likely related to the combination of antioxidants and caffeine, according to Consumer Reports. Large amounts (>1,000mg) of green tea extract can be harmful to the liver, but this supplement contains a small amount.
  • Craving Control Blend (166mg): consists of Caralluma Fimbriata (C. Fimbriata) extract which comes from the C. Fimbriata plant native to India and is commonly used to suppress the appetite. This fact-checked article discusses additional benefits and research supporting the use of this extract.
Bio X4 Supplement Facts

Bio X4 Supplement Facts. Source – nucific.com

How Does It Work – The Science Behind Bio X4

The science behind Bio X4 Nucific is in the ingredients that together are meant to reduce total calorie intake, improve digestion, boost energy levels, and burn more calories to result in weight loss. One may specifically wonder why a company would add probiotics to a weight loss supplement, but Harvard Health discusses a positive link between good gut bacteria and weight management.

The article proposes good bacteria in your gut may reduce the total amount of calories your body absorbs, making it easier to lose weight or minimally maintain your current weight.

THE TRUTH ABOUT BIO X4 | TESTING A PRODUCT ADVERTISED ON YOUTUBE (Video Credit – Alex Jayne)

Bio X4 Pros & Cons

Pros

  • This product is likely to promote gut health and some weight loss
  • Research behind individual ingredients overall support the effectiveness of them
  • Supplement ingredients are from whole fruits and vegetables
  • Nucific donates a portion of every purchase to the Action Against Hunger organization
  • Significant number of positive customer reviews on Bio X4
  • Appears to be a reputable company, has a physical location, and offers support via phone and email
  • Nucific offers an extensive 90-day money back guarantee if you’re not fully satisfied with their product

Cons

  • Mild stomach pain and nausea may occur

People Also Ask – Questions and Answers

Q: How to take BIO X4?
A: Nucific suggests taking 1 capsule 3 times per day with meals. The company mentions you can increase to 2 capsules per meal, but you should not exceed 6 capsules per day.

Q: How long does a bottle of Bio X4 last?
A: For 90 capsules, Nucific Bio X4 costs $49.00. This works out to be $1.63 – $3.26 per day to take these. A single bottle will last you between 15 – 30 days.

Q: What is Bio X4 used for?
A: It is a dietary supplement that is used to control appetite and boost metabolism.

Q: Does Bio X4 help you lose weight?
A: Nucific BIO-X4 contains EGCG — a natural compound found in green tea, which has been shown in numerous studies to boost your metabolism and help your body burn more fat. According to the manufacturer, this potent metabolism booster can help you achieve a slimmer, lighter body — while giving you the energy to enjoy every minute of every day.

Q: How Much Does Bio X4 Cost?
A: You have the option to buy 1, 3, or 6 bottles at a time. Each bottle is a 1-month supply if 3 capsules are taken daily. Each order also includes free shipping:

  • 1 bottle = $99.00
  • 3 bottles = $261.36
  • 6 bottles = $487.08
  • All prices listed here are as they appear on the official Nucific website.

Q: How do I re-order Bio X4?
A: You can either make a one-time purchase when you visit the website. You can also subscribe to the website for an additional 10% discount every month. When you purchase Bio X4 from Nucific official website, you enjoy a 90-day money-back guarantee. In case you do not like your purchase, you can return it and get a refund.

Q: What are the side effects of Bio X4?
A: The Nucific website claims there are no known side effects with Bio X4 and for the most part, we agree and it appears to be one of the safer weight loss supplements on the market. However, there are minor cases of side effects such as constipation, bloating, and nausea.

Q: What if I Have a Health Condition?
A: Side effects from Bio X4 are likely to be minimal, but be sure to discuss this supplement with a healthcare provider prior to starting it to ensure there are no pre-existing health condition concerns or medication interactions.

Q: Is Bio X4 safe?
A: Although green tea extract in large amounts may be harmful to the liver, taking the recommended 300mg/day is very unlikely to cause issues. Bromelain and C. Fimbriata may promote gastrointestinal discomfort, but nothing too severe. You may want to avoid this supplement if you are allergic to pineapple.

Q: Is Bio X4 safe for Liver Cirrhosis patients?
A: As with any new dietary supplement like Bio X4, always check with a physician before beginning your regimen to make sure there is no interaction with any of your current medications.

Q: Is taking Bio X4 shortly before bedtime prohibitive of sleep?
A: You have to take quite a few capsules per day. Also, be sure not to take these capsules right before bed because the green tea extract may hinder your sleep patterns.

Q: I’m not exactly sure how this product helps with weight loss. Could you explain it some?
A: Nucific Bio X4 is one of many probiotic supplements available online. The company behind Bio X4, ‘Nucific’, claims it will help with weight loss, metabolism, digestion, and appetite. As of now, there’s limited evidence to suggest that probiotic supplements may lead to a small amount of weight loss, but only by about one pound.

Q: How long does it take for Bio X4 to work and show real results?
A: With Nucific Bio X4, it can take a couple of months (between 30 and 60 days) to see results. However, some users have noticed results sooner than that (within 2 to 3 weeks).

Q: What is Bio X4’s Return & Refund Policy?
A: Nucific offers a wonderful 90-day money-back guarantee for users who are not 100% satisfied with their purchase. Users just have to call the company and they’ll get their money back. The Contact link provides an email address, physical location, and phone number with hours of operation to reach them.

Bio X4 Alternatives

Brand Price Ingredients
Vital Reds $69.95 Green tea, Aronia berries, grape seed extract, mulberry extract, bitter melon extract
1MD Complete Probiotics Platinum $40.99 Bifidobacterium lactis, Lactobacillus acidophilus, and NutraFlora prebiotic fiber
Bio Complete 3 $80.00 CoreBiome, Sunfiber, ProDURA
Colon Detox Plus $24.80 Aloe Vera, Alfalfa Leaf, Cascara Sagrada, Buckthorn, Rhubarb
ActivatedYou Morning Complete $49 Aloe Vera, Green Tea, Turmeric, Ginger Root, Probiotic Blend, Astralagus, Fennel Seed, Spinach, Broccoli, Kale, Cinnamon Bark

All prices listed here are as they appear on their websites and are subject to change.

Bio X4 Customer Reviews & Results

Does Bio X4 really work? The majority of Bio X4 reviews are positive as many reported curbed cravings, weight loss, elimination of bloating and indigestion, increased energy levels, and no side effects.

“Bio-X4 has made all the difference in my digestion!” — I found Nucific Bio-X4 by chance and understood from the promotional video that this product could be the answer I was looking for. I’ve had several rounds of antibiotics and have tried probiotic supplements that did not reach my intestinal tract, where they’re needed most. I considered the four ingredients in Bio-X4 and how they are made and decided it was worthwhile trying for 30 days (in conjunction with the excellent recipes provided).

I received Bio-X4 within a few days and have been taking them for 11 days. I am extremely happy to say that I can feel a vast difference in my health and my energy! I felt a small adjustment to my digestion which aligns with the healing expected by introducing good bacteria and have since noticed a great improvement in my skin, my movement, and my digestion! Considering this has been 11 days, I fully intend to continue with Bio-X4 and would highly recommend anyone who is suffering from digestion/weight issues to seriously consider Bio-X4. ~ by Cicely Doell

Negative reviews mainly revolved around complaints of incomplete shipments/shipping errors.

Where can I buy Bio X4?

The safest way to purchase Bio X4 is from the Nucific official website. You may not find this product in stores.

The Bottom Line

Bio X4 weight loss supplement seems to be an effective supplement with the intriguing addition of probiotics and an overwhelming amount of positive results. If you can get your hands on this supplement, it may very well be worth any type of hassle. The science is there and not only may it benefit your gut, but your waistline too!

Is There Anything Else I Should Know About Bio X4 Probiotics?

Keep in mind there is no such thing as a miracle weight loss pill, as much as it seems like this might be it. The company recommends you give Bio X4 at least 60 days to do its thing.

If you keep your expectations reasonable, you may be able to greatly benefit from this supplement.

Where Can You Buy Bio X4?

You can BUY it directly from the manufacturer’s Official Website

References

BIO X4 - Supporting Studies - https://nucific.com/3harmfulfoods/studies.php
ISRN Nutr. 2013; 2013: 481651. Published online 2013 Jan 2. doi: 10.5402/2013/481651 Health Benefits of Probiotics: A Review
Green tea for weight loss and weight maintenance in overweight or obese adults. Cochrane Systematic Review - Intervention Version published: 12 December 2012
https://doi.org/10.1002/14651858.CD008650.pub2
J Nutr. Author manuscript; available in PMC 2008 Nov 25. Published in final edited form as: J Nutr. 2008 Sep; 138(9): 1677–1683. doi: 10.1093/jn/138.9.1677 The Major Green Tea Polyphenol, (-)-Epigallocatechin-3-Gallate, Inhibits Obesity, Metabolic Syndrome, and Fatty Liver Disease in High-Fat–Fed Mice
J Nutr Metab. 2010;2010:285301. doi: 10.1155/2010/285301. Epub 2010 Dec 28. Antiobesogenic and Antiatherosclerotic Properties of Caralluma fimbriata Extract. Kamalakkannan S, Rajendran R, Venkatesh RV, Clayton P, Akbarsha MA.
Perspect Clin Res. 2015 Jan-Mar; 6(1): 39–44. doi: 10.4103/2229-3485.148812 To evaluate efficacy and safety of Caralluma fimbriata in overweight and obese patients: A randomized, single blinded, placebo control trial
Clin Nutr. 2016 Jun;35(3):592-9. doi: 10.1016/j.clnu.2015.05.003. Epub 2015 May 29. Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial. Chen IJ, Liu CY, Chiu JP, Hsu CH.
Appetite. 2007 May;48(3):338-44. Epub 2006 Nov 13. Effect of Caralluma fimbriata extract on appetite, food intake and anthropometry in adult Indian men and women. Kuriyan R, Raj T, Srinivas SK, Vaz M, Rajendran R, Kurpad AV.
Probiotics. Am J Health Syst Pharm. 2010 Mar 15;67(6):449-58. doi: 10.2146/ajhp090168. Williams NT. DOI: 10.2146/ajhp090168
Probiotic use in clinical practice: what are the risks? DOI: 10.1093/ajcn/83.6.1256 Am J Clin Nutr. 2006 Jun;83(6):1256-64; quiz 1446-7. Boyle RJ, Robins-Browne RM, Tang ML.
Katie J. Astell, Michael L. Mathai, Andrew J. McAinch, Christos G. Stathis, Xiao Q. Su. A pilot study investigating the effect of Caralluma fimbriata extract on the risk factors of metabolic syndrome in overweight and obese subjects: a randomised controlled clinical trial. Biomedical and Lifestyle Diseases (BioLED) Unit, College of Health and Biomedicine, Victoria University, Melbourne, Victoria 3021, Australia.
M. Million, et al. Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii. International Journal of Obesity (2012) 36, 817–825; doi:10.1038/ijo.2011.153; published online 9 August 2011
Perano SJ,Couper JJ,Horowitz M, Martin AJ, Kritas S, Sullivan T, Rayner CK. Pancreatic enzyme supplementation improves the incretin hormone response and attenuates postprandial glycemia in adolescents with cystic fibrosis: a randomized crossover trial. J Clin Endocrinol Metab. 2014 Jul;99(7):2486-93. doi: 10.1210/jc.2013-4417. Epub 2014 Mar 26.

Nucific Bio X4 Customer Reviews and Complaints

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Average Customer Rating:4.4 
10 Customer Reviews

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    By Micheline 

    More regular toilet habits / Weight loss / Less cravings

    I took Bio X4 as an attempt to make my digestion easier. 1 month into the program, I am delighted to see I’m losing weight (about 7 pounds!). Digestive wise I would say I feel the same (lots of action – movement and noise – at night in my belly!) but I certainly enjoy going to the bathroom every morning (I used to skip a day, sometimes 2!). Overall I am quite pleased with this product. I eat less and I don’t snack between meals anymore (I just don’t feel hungry!) without feeling deprived. Also, I love the little journal to write my meals – it helps me not to cheat! 🙂

    By Peggy East 

    Good product, It’s taking the weight off

    I ordered this product to help me lose weight. It’s doing just that. The pounds are coming off a little slower than I would like but the main thing it’s working! Thank you Bio X4.

    By Cynthia Scott 

    Great product! Already my digestion is better.

    This product so far has helped my digestion, and I don’t feel so hungry. I’ve only used it for about a month, but already I feel more regular.

    By Eric 

    Curbing my horrible food cravings

    I’ve noticed that my cravings decrease when I take the pills. I will admit that I do not take them all the time, I have a plethora of health issues, and meds, so I want to slowly introduce this into my routine. But when I do take it I notice that I am not nearly as hungry as when I do not take it.

    By Andrew L. 

    Feeling really good. Just keep moving

    Hello, I have been taking Bio X4 for about three weeks. I walk two miles every morning along with drinking my daily lemon water. BioX4 is helping me with my digestion. I have not really seen a big change in my weight, but my stomach fat is getting smaller. My wife says it usually takes about a month before you start seeing the difference. I have a week and a half to go. I’ll keep you updated.

    By Brian Turner 

    It's great and it helps me with my cravings

    I take it to help with controlling my bad food habits and since I been taking it to control me with sugar intake and have more energy and I want less coffee in the morning and I don’t have anything reaction to the product since I been taking it for about two weeks now.

    By Vicky 

    Pressing forward with a smile.

    Im taking Bio 4x because I’m stalled in my weight loss journey? I have not lost much but my body is reshaping. My goal is to be healthy and active at about 135. I started out four years ago at 350. I had a sleeve at 255 and now I’m struggling to breach the one hundred. I used to have high blood pressure and type two diabetes. I also have had a total hip replacement after being immobile and grounded to a walker for 12 years. I have more energy and have joined a gym for the first time in my life at almost 69 and am working on strength, balance, and endurance for my very first vacation in August.

    By David Gibb 

    I have lost almost 10 pounds for doing nothing

    I’ve never been fat gotten fat couldn’t lose it been on it for 3weeks…I’ve always been thin I could eat anything and everything and not gain an ounce turned 50 and I gained 70 pounds I bought every diet pills out there sometimes I would take 2 or 3 different ones a day but kept getting fatter but saw this video on Facebook and I decided to give it a chance and for 3 weeks all I’ve done is take the pills before I eat and because of my work schedule I haven’t done any exercise just taking the pills and I’ve lost 10 pounds I love these pills.

    By Whitney Weinstein 

    Lost some weight and clothes are looser

    I am 72. Not fit because I cannot exercise because of a back problem and general weakness. I have no scale but all my jeans are falling off me. I use a belt to keep them on. Even my hips appear narrower.

    By Susie 

    Bio X4 is a great product and I will continue to use.

    I have been taking Bio X4 for a while now and I feel good except for some aches and pains that I associate with my age. I like the products and research that goes into development. I sleep well at night and get up in the morning without dragging around. I have never had any adverse reaction to this product and I will continue to use it. Thank you Dr. Lee.

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