Synbiotic 365 Review – Is Synbiotic 365 Probiotic By United Naturals Safe?

Synbiotic 365 is a digestive health supplement that promises to restore gut flora, which helps to keep the digestive system in good shape, as well as lower food cravings and relieve bloating.

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5 sources

Health Insiders relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

[1] Hall JL. Vitamin B-Complex Deficiencies. J Natl Med Assoc. 1942 May;34(3):91-8. PMID: 20893101; PMCID: PMC2624995.

[2] Thiamine Acquisition Strategies Impact Metabolism and Competition in the Gut Microbe Bacteroides thetaiotaomicron

[3] Mirella Meyer-Ficca, James B Kirkland, Niacin, Advances in Nutrition, Volume 7, Issue 3, May 2016, Pages 556–558, https://doi.org/10.3945/an.115.011239

[4] Parra, M.; Stahl, S.; Hellmann, H. Vitamin B6 and Its Role in Cell Metabolism and Physiology. Cells 2018, 7, 84. https://doi.org/10.3390/cells7070084

[5] Margaret E. Brosnan, Luke MacMillan, Jennifer R. Stevens, John T. Brosnan; Division of labour: how does folate metabolism partition between one-carbon metabolism and amino acid oxidation?. Biochem J 1 December 2015; 472 (2): 135–146. doi: https://doi.org/10.1042/BJ20150837

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Our Top Rated Probiotic Supplements

Here are our top picks for the most effective Probiotic supplements currently available in the market, as per our assessment.

Overall Grade: A+

#1. WOWMD Good Gut Great Life

  • Supports Daily Energy*
    Supports Digestive HealthStrong Evidence
  • Supports Immune Function*
    Supports Regular Bowel MovementsStrong Evidence
  • Promotes Digestive Balance*
    Reduces Belly FatStrong Evidence
  • Supports Regular Bowel Movements*
    Maintain Cholesterol Levels Moderate Evidence
WOWMD Good Gut Great Life

Rating Breakdown

  • Ingredients star rating 4 8
  • Effectiveness star rating 4 8
  • Safety star rating 4 8
  • Cost star rating 4 8

Overall Rating

Overall Rating4.9
Overall Grade: A+

#2. Superfood Greens Fusion

  • Supports Natural Energy*
    Supports Digestive HealthStrong Evidence
  • Promotes Digestive Health*
    Promotes Weight ManagementStrong Evidence
  • Strengthens Immune Function*
    Enhances Immune FunctionStrong Evidencee
  • Supports Mental Clarity*
    Improves Mental Health Moderate Evidence
superfood-greens-fusion

Rating Breakdown

  • Ingredients star rating 4 8
  • Effectiveness star rating 4 7
  • Safety star rating 4 7
  • Cost star rating 4 8

Overall Rating

Overall Rating4.9
Overall Grade: A+

#3. Greens Blend

  • Support Heart Health*
    Supports Digestive HealthStrong Evidence
  • Improve Eye health*
    Supports Regular Bowel MovementsStrong Evidence
  • Promote Bone Health*
    Reduces Belly FatModerate Evidence
  • Improve Gut Health*
    Maintain Cholesterol Levels Strong Evidence
wowmd-greens-blend

Rating Breakdown

  • Ingredients star rating 4 8
  • Effectiveness star rating 4 8
  • Safety star rating 4 8
  • Cost star rating 4 8

Overall Rating

Overall Rating4.9
Overall Grade: A+

#1. Flawless Bloom Greens Superfood

  • Supports Daily Energy*
    Supports Digestive HealthStrong Evidence
  • Supports Immune Function*
    Supports Regular Bowel MovementsStrong Evidence
  • Promotes Digestive Health*
    Reduces Belly FatStrong Evidence
  • Provides Antioxidant Support*
    Maintain Cholesterol Levels Moderate Evidence
greens-superfood

Rating Breakdown

  • Ingredients star rating 4 8
  • Effectiveness star rating 4 8
  • Safety star rating 4 8
  • Cost star rating 4 8

Overall Rating

Overall Rating4.8
Overall Grade: A

#5. Bioma Probiotics

  • Supports Healthy Digestion*
    Supports Digestive HealthStrong Evidence
  • Promotes Weight Management*
    Promotes Weight ManagementStrong Evidence
  • Enhances Immune Function*
    Enhances Immune FunctionStrong Evidencee
  • Improves Mental Health*
    Improves Mental Health Moderate Evidence
bioma

Rating Breakdown

  • Ingredients star rating 4 8
  • Effectiveness star rating 4 7
  • Safety star rating 4 7
  • Cost star rating 4 8

Overall Rating

Overall Rating4.8

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Synbiotic 365 Customer Reviews and Complaints

Review this product and share your thoughts with other customers

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Average Customer Rating:2.9 
32 Customer Reviews

Rating Snapshot:

Excellent 
6
Great 
9
Average 
5
Poor 
1
Bad 
11
Bottom Line: 63% would recommend it to a friend
    By Andrew Morrison 
    VerifiedThe "Verified Reviewer" authentication is just one more way that we strive to bring our readers the most accurate and reliable information.
    Andrew Morrison,  was invited to write this review Learn More
    August 4, 2026 at 5:31 am

    Good Ingredients Yet Limited Noticeable Benefits

    Synbiotic 365 wasn’t a bad supplement, but I expected stronger support after consistent daily use. I experienced slight improvements in gut health, though the overall results weren’t significant enough to justify purchasing another bottle.

    By Melissa Carter 
    VerifiedThe "Verified Reviewer" authentication is just one more way that we strive to bring our readers the most accurate and reliable information.
    Melissa Carter,  was invited to write this review Learn More
    August 1, 2026 at 6:37 am

    Decent Formula But Results Felt Average

    The supplement didn’t cause any major side effects, and I appreciated the blend of probiotics and vitamins. However, the changes in my digestive comfort were fairly subtle, making the overall experience feel only average.

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