
Overview
Still planning to hit the gym? We’re all in the race to, you know, feel better, and fill the gaps where life’s demands leave us short.
Supplements might just be the missing piece in your wellness puzzle. For men, they’re more than just a boost—they’re a way to bridge nutritional gaps, enhance performance, and support long-term health.
Whether it’s fueling your workouts, improving recovery, or safeguarding your heart and mind, the right supplements can make all the difference. But with so many options, finding what works for you can feel overwhelming. That’s why today, we help you choose the best supplements for men. Read along.
How We Researched and Selected the Best Supplements for Men?
Methodology
To ensure the recommendations in this guide are both reliable and effective, we employed a rigorous research methodology. We evaluated each product based on its scientific backing, ingredient quality, and real-world performance.
We prioritized products with clinical evidence supporting their claims, ensuring they deliver measurable benefits.
We also paid special attention to User reviews and expert opinions to gauge customer satisfaction and practical outcomes.
Criteria for Evaluation
- Effectiveness: Each supplement was evaluated for its ability to deliver measurable health benefits. We relied on clinical evidence and scientific studies to confirm claims, ensuring the products are backed by data rather than marketing hype.
- Safety: Safety was paramount. We scrutinized products for potential side effects, interactions with medications, and the presence of harmful contaminants. Supplements with third-party testing for safety and purity were given preference.
- Ingredient Quality: High-quality, bioavailable ingredients were a non-negotiable criterion. We prioritized supplements with clean labels, free from unnecessary fillers, artificial additives, or allergens.
- Customer Feedback: Real-world user reviews were analyzed to understand how the supplements performed in everyday scenarios.
- Value for Money: Affordability was balanced with quality. We compared the cost per serving to ensure that the supplements offered good value without compromising on effectiveness or safety.
Our Top Picks
Best Supplement for Male Vitality & Testosterone: WOWMD Testosterone Support
Ultimate Male Performance Supplement: PeakErect
Best Supplement for Prostate Health & Urinary Comfort: WOWMD Prosta Defend
Best Performance Supplement for Men 40+: WOWMD Perform Max
Best Prostate Support Supplement for Men: Prostate SP
Best Supplement for Circulation & Vitality: WOWMD L-Arginine Plus
Best Supplements for Men’s Health over 40: ProstaVive
Best Multivitamin Supplements for Men: Vimerson Health Multivitamin for Men
Best Supplements for Skinny Guys to Gain Muscle Mass: Optimum Nutrition Serious Mass
Best Supplements for Men
WOWMD Testosterone Support – Best Supplement for Male Vitality & Testosterone

*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
- Comfort 4.9/5
- Effectiveness 4.9/5
- Convenience 4.8/5
- Value 4.9/5
WOWMD Testosterone Support is a premium supplement designed to help maintain healthy testosterone levels, enhance energy, and promote overall male vitality. With potent ingredients like Tribulus Terrestris, Tongkat Ali, and Saw Palmetto, it supports natural testosterone production, boosts physical performance, and promotes prostate health, making it an excellent choice for men seeking to improve their vitality and well-being.
Key Specs
- Form: Capsules
- Type: Supplement
- Brand: WOWMD
- Benefit: Supports healthy testosterone levels, boosts energy, enhances performance, promotes prostate health
- Active Ingredients: Tribulus Terrestris, Tongkat Ali, Saw Palmetto, Chinese Hawthorn Berries, Magnesium, Zinc
- Dosage: 3 capsules daily
- Price: $71.10*
WOWMD Testosterone Support Pros & Cons
Pros
- Supports natural testosterone production
- Enhances energy, stamina, and performance
- Promotes prostate health
- Vegan, gluten-free, non-GMO
- Made in the USA
- 60-day money-back guarantee on your first single bottle purchases
Cons
- Results may vary from person to person
- Online Purchase Only
- Requires consistent use for optimal benefits
WOWMD Testosterone Support Customer Reviews
Endurance for Days
It’s like a shot of energy that keeps me going all day—workouts have never felt better! – Todd C.
Vitality Restored
I feel like a whole new man, energy levels through the roof and no crashes! – Jason M.
Summary: WOWMD Testosterone Support promotes healthy testosterone levels, boosts energy, and supports overall vitality. Customers report increased strength, faster recovery, and improved workouts. With natural ingredients and proven results, it’s an excellent choice for men looking to enhance their performance and well-being.
PeakErect – Ultimate Male Performance Supplement

*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
- Comfort 4.8/5
- Effectiveness 4.9/5
- Convenience 4.8/5
- Value 4.9/5
PeakErect is a premium male performance supplement designed to enhance stamina, vitality, and sexual performance. It features a blend of natural ingredients like L-Arginine, Siberian Ginseng, and Tribulus Terrestris, which help boost circulation, increase libido, and improve overall vitality, making it an excellent choice for men seeking peak performance.
Key Specs
- Form: Tablet
- Type: Supplement
- Brand: Flawless Bloom
- Benefit: Enhances sexual stamina, boosts energy, improves circulation for firmer erections
- Active Ingredients: L-Arginine, Siberian Ginseng, Tribulus Terrestris, Maca Root, Longjack
- Dosage: 2 tablets daily
- Price: $68.00*
PeakErect Pros & Cons
Pros
- Boosts stamina, energy, and libido
- Supports improved circulation for better performance
- Made with natural, science-backed ingredients
- Gluten-free, non-GMO, no artificial additives
- 60-day money-back guarantee
Cons
- Requires consistent daily use for best results
- Results may vary depending on individual factors
PeakErect Customer Reviews
Boosted My Libido
I’ve noticed a significant boost in my libido since starting this product. I feel more confident and ready to perform! – James H.
Great product that works!
Man, I’ve been using PeakErect for about two months now, and the change is unreal. I feel younger, stronger, and way more confident. My energy is through the roof and the stamina is legit. It’s like I’ve hit the reset button on my body. This stuff works!!! – Bart K.
Summary: PeakErect is a potent supplement that boosts male vitality, performance, and stamina. With its natural, science-backed ingredients, users experience enhanced energy, better circulation, and improved sexual confidence, making it an essential addition to daily wellness routines for men.
WOWMD Prosta Defend – Best Supplement for Prostate Health and Urinary Comfort

*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
- Comfort 4.9/5
- Effectiveness 4.8/5
- Convenience 4.8/5
- Value 4.9/5
WOWMD Prosta Defend is a high-potency prostate support formula designed to enhance urinary health, reduce nighttime urination, and promote overall prostate wellness. Combining Saw Palmetto, Green Tea Extract, and L-Glycine, this supplement provides natural support for maintaining prostate size and optimizing urinary function, making it ideal for men seeking to improve prostate health and comfort.
Key Specs
- Form: Capsule
- Type: Supplement
- Brand: WOWMD
- Benefit: Supports prostate health, improves urinary flow, reduces nighttime urination
- Active Ingredients: Saw Palmetto, Green Tea Extract, L-Glycine
- Dosage: 2 capsules daily
- Price: $62.10*
WOWMD Prosta Defend Pros & Cons
Pros
- Supports prostate health and function
- Improves urinary comfort and reduces frequent urination
- Helps maintain overall male wellness
- Non-GMO, gluten-free, vegan-friendly
- 60-day money-back guarantee
Cons
- Requires consistent daily use for optimal results
- Individual results may vary based on lifestyle and health
WOWMD Prosta Defend Customer Reviews
Great Value & Relief
Fantastic product, I’m seeing fewer bathroom runs, feel more active! – Bryan M.
Noticeable Improvement
Saw results in just a few weeks, my prostate feels so much better now. – Lois G.
Summary: WOWMD Prosta Defend is a potent supplement that supports prostate health, improves urinary function, and reduces nighttime urination. Users report enhanced comfort and better sleep, making it a great choice for men seeking to maintain prostate wellness and overall vitality.
WOWMD Perform Max – Best Performance Supplement for Men 40+

*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
- Comfort 4.7/5
- Effectiveness 4.9/5
- Convenience 4.8/5
- Value 4.8/5
WOWMD Perform Max is designed for men over 40 to support stamina, energy, and confidence. Packed with L-Arginine, Maca, and Longjack, it enhances endurance, boosts libido, and promotes peak performance, helping you perform better physically and maintain high vitality, making it an ideal choice for men seeking to optimize their health.
Key Specs
- Form: Tablet
- Type: Supplement
- Brand: WOWMD
- Benefit: Boosts stamina, energy, and libido, enhances physical performance
- Active Ingredients: L-Arginine HCL, Longjack, Maca Root, Zinc, Ginseng
- Dosage: 2 tablets daily
- Price: $71.10*
WOWMD Perform Max Pros & Cons
Pros
- Boosts stamina, energy, and libido
- Supports confidence and overall vitality
- Helps improve physical performance and endurance
- Gluten-free, non-GMO, no artificial additives
- Get 60-day money-back guarantee on your first single bottle purchases
Cons
- Requires consistent use for best results
- Online Purchase Only
- Results may vary from person to person
WOWMD Perform Max Customer Reviews
Boosted energy and better stamina
Using Perform Max for a bit now. More energy, better stamina, and libido’s improving. Confidence is up too. I’m sticking with it! – Larry M.
Perform max helps when it counts
My drive kicks in quick with these, and while you still gotta stay active, they definitely help me perform better when it matters. – Devan R.
Summary: WOWMD Perform Max boosts stamina, energy, and libido, helping men 40+ perform at their best. Customers report increased energy, enhanced confidence, and better performance, making it a great addition to daily routines for sustained vitality and physical function.
Prostate SP – Best Prostate Support Supplement for Men

*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
- Comfort 4.7/5
- Effectiveness 4.9/5
- Convenience 4.8/5
- Value 4.7/5
ProstateSP is a scientifically formulated supplement designed to support prostate health, improve urinary flow, and reduce nighttime bathroom trips. With natural ingredients like Saw Palmetto, Pygeum Africanum, and Zinc, it promotes optimal prostate size management and enhances overall comfort, making it an ideal choice for men seeking prostate wellness.
Key Specs
- Form: Capsule
- Type: Supplement
- Brand: Flawless Bloom
- Benefit: Supports prostate health, improves urinary flow, reduces nighttime trips
- Active Ingredients: Saw Palmetto, Pygeum Africanum, Zinc, Vitamin E, Green Tea Extract, Raspberry Juice Powder, Graviola
- Dosage: 2 capsules daily
- Price: $67.20*
ProstateSP Pros & Cons
Pros
- Reduces frequent nighttime urination
- Supports healthy prostate size and function
- Improves urinary flow and comfort
- Natural, science-backed ingredients
- Gluten-free, non-GMO, no artificial additives
- 60-day money-back guarantee
Cons
- Results may vary from person to person
- Requires consistent use for optimal benefits
ProstateSP Customer Reviews
Prostate SP: A Trusted Supplement
The natural ingredients make a real difference in my comfort level. I highly recommend Prostate SP. – Jared Y.
Improved Daily Comfort
This product gave me noticeable relief in just a short amount of time. Very pleased with the results! – Hank L.
Summary: ProstateSP supports prostate health and urinary function, helping men improve comfort and reduce nighttime trips. Customers report enhanced comfort and better sleep, making it a reliable choice for men seeking improved prostate wellness.
WOWMD L-Arginine Plus – Best Supplement for Circulation and Vitality

*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
- Comfort 4.7/5
- Effectiveness 4.7/5
- Convenience 4.8/5
- Value 4.8/5
WOWMD L-Arginine Plus is formulated to improve circulation, enhance endurance, and support overall vitality. Packed with 400 mg of L-Arginine per serving, along with other powerful ingredients like Niacin and L-Citrulline, it boosts nitric oxide levels, ensuring better blood flow, improved workout performance, and faster muscle recovery. It’s perfect for those seeking increased energy, vitality, and better physical performance.
Key Specs
- Form: Capsule
- Type: Supplement
- Brand: WOWMD
- Benefit: Supports circulation, boosts energy, enhances endurance and recovery
- Active Ingredients: L-Arginine, L-Citrulline, Niacin, Calcium, Mallow Extract
- Dosage: Two (2) capsules daily
- Price: $52.20*
WOWMD L-Arginine Plus Pros & Cons
Pros
- Supports healthy blood flow
- Enhances endurance and energy
- Ideal for workout recovery
- Non-GMO, gluten-free, vegan
- No artificial additives
- Enjoy 60-day money-back guarantee on your first single bottle purchases
Cons
- Regular use required for best results
- May cause mild digestive discomfort for some users
- Results may vary based on individual conditions
WOWMD L-Arginine Plus Customer Reviews
Helps me power through workouts
This supplement boosts my endurance and speeds up recovery. I feel more energized and stronger during workouts. – Kirill S.
Better blood flow and circulation
I take it for better blood flow, and I can feel the difference. Circulation’s improved. – Rob P.
Summary: WOWMD L-Arginine Plus promotes healthy blood flow, energy, and workout recovery. Users rave about its benefits, like better endurance and faster recovery, making it a top choice for boosting vitality and supporting physical performance.
ProstaVive – Best Supplements for Men’s Health over 40

*All the prices listed here are as they appear on their websites and are subject to change.
Our Rating
- Comfort 4.6/5
- Effectiveness 4.7/5
- Convenience 4.8/5
- Value 4.6/5
ProstaVive is a natural supplement formulated to boost prostate health, improve urine flow, and enhance sexual performance. With ingredients like Boron, Tongkat Ali, and Maca Root, ProstaVive supports blood flow, prostate function, and energy levels, providing men with the ultimate support for prostate and urinary health.
Key Specs
- Form: Powder
- Type: Supplement
- Brand: ProstaVive
- Benefit: Enhances prostate health, promotes strong urine flow, supports sexual function
- Active Ingredients: Boron, Tongkat Ali, Ashwagandha, Maca Root, Fenugreek, Panax Ginseng, Artichoke Extract, Nettle Root, Zinc, Magnesium, Vitamin D
- Dosage: 1 scoop daily with water
- Price: $79.00*
ProstaVive Pros & Cons
Pros
- Supports prostate health and blood circulation
- Improves urine flow and sexual function
- Boosts energy and vitality
- Contains natural ingredients
- Helps maintain healthy nitric oxide levels
Cons
- Results may vary from person to person
- Needs consistent use for optimal results
- Available only through the official website online
ProstaVive Customer Reviews
Since I started taking ProstaVive, I’ve noticed a huge difference in my energy levels and overall prostate health. My sleep quality has improved, and I feel more confident in my day-to-day life. Highly recommend it to men over 40! – Thomas R.
ProstaVive has really boosted my energy and helped with my prostate health; I feel more confident and active every day! – James W.
Summary: ProstaVive is a powerful prostate health supplement that improves blood circulation, urine flow, and sexual function. With its unique blend of natural ingredients, it’s a great choice for men seeking enhanced prostate health, energy, and overall vitality.
Vimerson Health Multivitamin for Men – Best Multivitamin Supplements for Men

Our Rating
- Comfort 3.9/5
- Effectiveness 3.9/5
- Convenience 3.8/5
- Value 3.9/5
Vimerson Health Men’s Multivitamins is a comprehensive supplement formulated to support overall men’s health. With key vitamins and minerals like Vitamin B12, D3, Magnesium, and Zinc, it aims to boost energy, support immune function, and promote mental clarity. However, the effects may vary from person to person, and some users may experience stomach discomfort.
Key Specs
- Form: Capsule
- Type: Supplement
- Brand: Vimerson Health
- Benefit: Supports energy, immunity, bone health, and mental clarity
- Active Ingredients: Vitamin A, Vitamin C, Vitamin D, Vitamin E, Vitamin B-complex, Magnesium, Zinc, Selenium, Copper, Manganese
- Dosage: 2 capsules daily
- Price: $30.99*
- Where to Buy: Amazon
Vimerson Health Multivitamin for Men Pros & Cons
Pros
- Supports energy levels and mental clarity
- Includes bioavailable forms for better absorption
- Supports immune health and overall wellness
Cons
- Results may vary depending on individual health factors
- Some users report stomach discomfort or nausea
- May not be suitable for individuals with specific vitamin sensitivities
Vimerson Health Multivitamin for Men Customer Reviews
Mixed Results
I’ve been taking these for a few weeks, but I haven’t noticed a huge difference in my energy or focus. The vitamins are easy to swallow, but I did experience some stomach issues when I first started. – Andrew T.
Energy Boost but Some Discomfort
These vitamins give me a good energy boost, but I’ve had some stomach bloating and discomfort. They’re okay overall, but I was hoping for more noticeable benefits. Might try something else next time. – Peter M.
Summary: Vimerson Health Men’s Multivitamins provide basic nutritional support, boosting energy and immunity. While the bioavailable ingredients are beneficial for most, some users experience mild stomach discomfort. A solid option but may not work for everyone.
Optimum Nutrition Serious Mass – Best Supplements for Skinny Guys to Gain Muscle Mass

Our Rating
- Comfort 3.7/5
- Effectiveness 3.7/5
- Convenience 3.8/5
- Value 3.7/5
Optimum Nutrition Serious Mass is a weight gainer designed for those aiming to increase muscle mass and overall body weight. It combines protein and carbohydrates with added vitamins and minerals to support growth and recovery. However, the large serving size and sweet taste may be too much for some users, and it could cause discomfort or bloating.
Key Specs
- Form: Powder
- Type: Weight Gainer Supplement
- Brand: Optimum Nutrition
- Benefit: Supports muscle growth and weight gain
- Active Ingredients: Protein blend (Whey Protein Concentrate, Caseinate, Egg Albumen), Creatine, Vitamin C, Zinc, Maltodextrin
- Dosage: 2 scoops (340g) daily
- Price: $75.94*
- Where to Buy: Amazon
Optimum Nutrition Serious Mass Pros & Cons
Pros
- Supports muscle growth and weight gain
- Includes creatine for improved performance
- Contains a blend of vitamins and minerals
Cons
- Large serving size may cause discomfort
- Overly sweet taste may not suit all users
- Potential for bloating and digestive issues
- May not be ideal for low-calorie diets
Optimum Nutrition Serious Mass Customer Reviews
Effective but Too Sweet
I’ve gained some muscle mass, but the taste is just too sweet for me. I had to mix it with a lot of milk to dilute the flavor. – Carlos G.
Good for Hard Gainers
As a hard gainer, Serious Mass has helped me pack on weight, but I struggled with bloating and feeling too full. – Tom L.
Summary: Optimum Nutrition Serious Mass is effective for weight gain, but its large serving size and sweet taste can cause discomfort and bloating for some users. It’s better suited for those looking to consume a high-calorie supplement.
How to Choose the Right Supplements for Men?
- Understand Your Needs: Start by identifying your health goals. Are you looking to boost energy, improve muscle recovery, or support overall wellness? Your specific needs will guide your choices.
- Check the Label: Always read the supplement label carefully. Ensure the product contains clinically effective ingredient doses. Look for seals like NSF, USP, or GMP, which verify quality and safety.
- Research the Brand: Choose reputable brands with a history of quality and transparency. Check if the company uses third-party testing to verify purity and potency.
- Consult a Healthcare Professional: Before starting any supplement, talk to your healthcare provider or a registered dietitian. They can help you determine what’s safe and effective.
- Consider Value for Money: Compare the cost per serving rather than the total price. A higher price doesn’t always mean better quality, but extremely cheap products may compromise on safety or effectiveness.
Do Supplements for Men Work?
Supplements can be effective, but their success depends on several factors. They are not magic pills but tools to support your health when used correctly.
For men, supplements like multivitamins, omega-3s, and protein powders can fill nutritional gaps, enhance performance, and support overall well-being. But, there’s a catch – you have to choose high-quality products, and use them correctly and consistently.
Scientific evidence backs many supplements. For example, creatine is proven to improve muscle strength, while vitamin D supports bone health and immunity.[1][2] Remember, results vary based on individual needs, lifestyle, and diet. Supplements work best when paired with a balanced diet, regular exercise, and healthy habits.
Common Ingredients in the Best Supplements for Men

Vitamin D
This essential nutrient helps maintain bone health, support immune function, and regulates testosterone levels.[3] Many men are deficient in vitamin D due to limited sun exposure, so supplementation goes a long way.

Omega-3 Fatty Acids
Found in fish oil, omega-3s are well-known for their ability to reduce inflammation, support heart health, and improve brain function.[4]

Magnesium
This mineral is involved in over 300 biochemical reactions in the body. Magnesium is essential for muscle function, energy production, and stress regulation.[5] It is especially important for active men and those with dietary gaps.

Zinc
This mineral is crucial for immune health, testosterone production, and prostate function.[6] Zinc deficiencies are common in men and can lead to hormonal imbalances.
Benefits of Men’s Supplements
Filling Nutritional Gaps: Even with a balanced diet, it can be challenging to meet all nutritional needs. Supplements like multivitamins provide essential nutrients to keep your body functioning.
Boosting Energy and Performance: These supplements are known to enhance energy production and improve physical performance. You especially need this if you’re involved in high-intensity activities.
Supporting Heart Health: These supplements contain ingredients that help reduce inflammation, lower triglycerides, and support cardiovascular health. This is crucial for men at risk of heart disease.
Improving Prostate Health: Some of these supplements contain ingredients that help manage symptoms of benign prostatic hyperplasia (BPH) and promote urinary function.
Are Supplements for Men Safe to Use?
Supplements can be safe when used correctly, but they are not without risks. High doses of certain nutrients, like vitamin D or zinc, may cause side effects such as nausea or calcium buildup.
Some supplements, especially those with stimulants, can raise blood pressure or heart rate, which is dangerous for individuals with underlying conditions.
Interactions with medications are another concern. For example, vitamin K can interfere with blood thinners, and St. John’s Wort may reduce the effectiveness of antidepressants or birth control. Always inform your healthcare provider about any supplements you take to avoid harmful interactions.
Unlike prescription drugs, supplements are not FDA-approved before hitting the market. This means quality can vary. To ensure safety, choose products from reputable brands that undergo third-party testing.
Be sure to consult a healthcare professional before starting.
Who Should Consider Using Men’s Supplements?
- Men with Nutritional Gaps: If your diet lacks essential nutrients due to a busy lifestyle, dietary restrictions, or limited food variety, supplements can help.
- Athletes and Active Men: Men engaged in intense physical activity may require additional nutrients to support muscle recovery, energy production, and endurance.
- Older Men: As men age, their bodies may absorb fewer nutrients like vitamin B12 and calcium. Supplements can help maintain bone density, cognitive function, and overall vitality.
- Men with Specific Health Concerns: Those with conditions like joint pain, low testosterone, or prostate issues may benefit from targeted supplements
Final Verdict
The world of dietary supplements is a confusing one. Too many products, all of which promise miracles, but very few actually work. So, how do you go past this noise and pick the best supplements for men? This guide has covered.
We discussed what to look for in a quality supplement, analyzed the science behind supplements for men, and listed some of the best picks in the market today.
All you have to do now is choose high-quality products tailored to your needs. Remember, supplements are not a replacement for a healthy diet but a way to enhance it. Keep your healthcare provider in the loop.
Frequently Asked Questions
Q: Do I really need supplements if I eat a balanced diet?
A: If your diet consistently provides all essential nutrients, supplements may not be necessary. However, gaps in nutrition due to lifestyle, age, or specific health needs can make supplements beneficial.
Q: Are supplements for men safe to take daily?
A: Most supplements are safe when taken as directed. However, excessive doses can cause side effects. Always follow recommended guidelines and consult a healthcare provider.
Q: Can supplements replace a healthy diet?
A: No, supplements are meant to complement your diet, not replace it. Whole foods provide additional nutrients and benefits that supplements cannot replicate.
6 Sources
Health Insiders relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.
[1] What is creatine? Potential benefits and risks of this popular supplement: https://www.health.harvard.edu/exercise-and-fitness/what-is-creatine-potential-benefits-and-risks-of-this-popular-supplement
[2] Vitamin D: https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional
[3] Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines: https://doi.org/10.3390/nu17020277
[4] Effects of Omega-3 Polyunsaturated Fatty Acids on Brain Functions: A Systematic Review: https://doi.org/10.7759/cureus.30091
[5] Magnesium and Human Health: Perspectives and Research Directions: https://doi.org/10.1155/2018/9041694
[6] Zinc and its importance for human health: An integrative review - PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC3724376/
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