Overview
Cholesterol can be sneaky and insidious because there is often very little sign that someone may have high cholesterol. You could be rail thin, muscular, and generally healthy, and still have high cholesterol and not even know it. So, how is someone supposed to keep their cholesterol levels healthy?
One way is to implement a dietary supplement that can help neutralize bad cholesterol. One such supplement is called CholestOff Complete. CholestOff Complete is made by a well-known, established, and highly regarded supplement manufacturer called NatureMade.
NatureMade products are sold in physical stores all over the country and are known for making high-quality supplements. But when it comes to CholestOff Complete, does the NatureMade quality shine through? What benefits, if any, does CholestOff Complete offer to consumers? Let’s talk about it in the following CholestOff Complete review.

CholestOff Complete Review – Health Insiders Images
What Is CholestOff Complete?
CholestOff Complete is a dietary supplement that may help lower LDL cholesterol levels. The claims associated with CholestOff Complete are that it will support cardiovascular function, lower dietary cholesterol, and even reduce LDL production. CholestOff Complete comes in capsule form and is only meant to be taken as a dietary supplement.
The makers of CholestOff Complete claim that much of the formula is devoted to natural plant sterols (as esters) that are particularly effective for neutralizing the effects of LDL cholesterol and may affect the liver in such a way that it is discouraged from producing LDL cholesterol in the first place.
So the general role of CholestOff Complete as a dietary supplement is to improve cardiovascular health, as high cholesterol could increase your risk of major cardiac events. For the most part, people take CholestOff Complete to offset the effects of poor dietary choices.
CholestOff Complete – Quick Facts & Specs

- Form: Capsule
- Type: Heart support
- Benefit: Lower LDL levels, Heart support
- Brand: NatureMade
- Price: $48.89*
- Number of Serving Per each Container: 40
- Active Ingredients: Pantethine, Phytosterols
Pros and Cons of CholestOff Complete

- Made by a reputable company
- You can buy it in stores
- No artificial flavors

- It contains gelatin
- Some users have said the capsules are too soft
- May cause stomach discomfort
- Some users have complained about headaches
- The capsules may stick together
- The effects may not be noticeable
How Does CholestOff Complete Work?
One of the more interesting claims made about this supplement is that it contains Phytosterols. Phytosterols are plant nutrients that may affect the human body in a variety of ways. In the case of CholestOff Complete, Phytosterols are supposed to work by reducing the cholesterol absorption rates in the organs.
The way that phytosterols are supposed to work is by replacing the absorption rate of cholesterol in the organs. In other words, Phytosterols take the place of cholesterol by absorbing into organs like the liver before cholesterol can. This may negate the negative effects of cholesterol, particularly bad LDL cholesterol.[1]
The absorption rate of phytosterols varies greatly from person to person, though. So CholestOff Complete is likely to work very differently for individual users. Plus, the formula for CholestOff Complete doesn’t contain much outside of Phytosterols, so the functionality of this supplement may be rather limited.
CholestOff Complete Ingredients
In this section, we will take a look at what scientific studies have discovered about how the ingredients in CholestOff Complete work:
Pantethine – There are 300 milligrams of pantethine in the formula for CholestOff Complete. Pantethine is basically a form of vitamin B5, which has been claimed to have benefits for cholesterol levels. Some studies have found that Pantethine may benefit cardiovascular function by lowering LDL cholesterol levels. The PubMed staff has reported that:
This study confirms that pantethine lowers cardiovascular risk markers in low to moderate CVD risk participants eligible for statins according to NCEP guidelines.[2]
However, while this sounds promising, there have also been divergent test results. Some studies have not come up with such concretely beneficial results when it comes to Pantethine, so its efficacy is likely to vary based on the user and their unique health history.
Phytosterols – Phytosterols are plant-based nutrients that have been classified as compounds. Some medical authorities have also noted that Phytosterols have similar structures to cholesterol, which is why it has been studied at length for their possible effect on cholesterol levels.[3]
The way that phytosterols are purported to work for lowering cholesterol is by inhibiting the absorption of cholesterol into major organs. This, in theory, would lower bad, LDL cholesterol levels and improve heart function. However, the National Institutes of Health have studied the cholesterol-lowering effects of phytosterols at length and have made the following statement about them:
Although phytosterols decrease LDL-cholesterol levels, there is no evidence that they reduce the risk of cardiovascular diseases.[4]
Furthermore, the makers of this supplement have not found it necessary to list exactly which phytosterols they have used for the CholestOff Complete formula.
Benefits of CholestOff Complete
Lower LDL Levels – The formula for CholestOff Complete includes phytosterols, which are supposed to displace cholesterol in the organs and block their absorption. However, this may not actually benefit cardiovascular health.
Lowers Dietary Cholesterol – When taken consistently and as directed by a healthcare practitioner, CholestOff Complete may lower total dietary cholesterol and offset the effects of poor dietary choices.
Cardiovascular Support – The manufacturers of CholestOff Complete claim that CholestOff Complete will support heart health, but the overall effects on cardiovascular function may only be moderate.
CholestOff Complete Side Effects
While the formula for CholestOff Complete is made of natural ingredients, there have still been a number of customer reviews that mention side effects. For instance, one user has said that this supplement caused insomnia, while another complained of bad headaches.
Is CholestOff Complete Safe?
The makers of CholestOff Complete say that there are no GMOs in the formula and that the formula is free of artificial dyes and colors. NatureMade has also omitted gluten from the formula to make it safe for as many users as possible. Still, you should ask your trusted healthcare practitioner about any new supplement you are thinking of taking, including CholestOff Complete.
CholestOff Complete Customer Reviews
Let’s take a look at how real CholestOff Complete customers have reacted to the product:
I received the supplements last week and took one tablet. I experienced severe stomach pain and a pounding headache that lasted for eight hours. After reviewing some of the one star reviews, I see that others have also have the same effect so do not purchase or take at your own risk. – Renne
Caused INSOMNIA, and RAISED BLOOD PRESSURE. Not for me. I only too 2 pills per day. – Emily
I like this Cholestoff softgels, I been use for a while and I can see the results when I visit the doctor and gives me my results!! – Ronald
How to Use CholestOff Complete?
The makers of CholestOff Complete say that you should take 3 capsules twice a day with your two largest meals of the day. It would also be a good idea for prospective CholestOff Complete users to ask their physician how to safely use this product.
How Much Does CholestOff Complete Cost?
On the official CholestOff Complete website, a single bottle of the product will cost $48.89. This is for a standard 120-count bottle. There is also a subscription offer that bumps the price for each bottle down to $44.
Where to Buy CholestOff Complete?
You can get CholestOff Complete on the official NatureMade website. It is also available on popular 3rd party retail sites like Amazon.
Final Verdict
CholestOff Complete is a supplement that is supposed to lower the user’s total dietary cholesterol levels. It may have a moderate effect towards this end, and some users have actually confirmed that it lowers LDL levels.
Still, the consumer should be aware that the overall effects of CholestOff Complete may be limited. There have also been concerning reports from customers about bad headaches and insomnia.
That’s why it would be best to compare CholestOff Complete carefully with other cholesterol supplements and to ask your healthcare practitioner about possible alternatives.
Frequently Asked Questions
Q: Does CholestOff Complete actually lower cholesterol?
A: Some users seem to think so. However, CholestOff Complete only contains a couple of active ingredients, so the effects may be limited overall.
Q: What safety concerns have people raised?
A: There have been some customers who have said that it caused their blood pressure to rise and that the supplement caused side effects like insomnia.
Q: What timeline have users mentioned?
A: The timeline for this supplement has varied from user to user. Some say it works after 2-4 weeks, while some people have never experienced any beneficial results.
Q: Does CholestOff Complete replace statins or other medications?
A: No. CholestOff Complete was not meant to replace any medications that your doctor may have you on. It is meant only to be taken as a dietary supplement.
4 Sources
Health Insiders relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.
[1] Phytosterols in the Treatment of Hypercholesterolemia and Prevention of Cardiovascular Diseases: https://pmc.ncbi.nlm.nih.gov/articles/PMC5729784/
[2] Pantethine, a derivative of vitamin B5, favorably alters total, LDL, and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation: https://pmc.ncbi.nlm.nih.gov/articles/PMC3942300/
[3] Phytosterols: https://my.clevelandclinic.org/health/drugs/17368-phytosterols-sterols--stanols
[4] Phytosterols in the Treatment of Hypercholesterolemia and Prevention of Cardiovascular Diseases: https://pmc.ncbi.nlm.nih.gov/articles/PMC5729784/
Was This Article Helpful ?
Yes
- No

Health Insiders Team
The Health Insiders Team takes pride in bringing you the latest in nutritional research, skincare, healthy living, and wellness hacks. Together our researchers, journalists, dermatologists, and health experts have decades of pertinent experience generating and editing content for Health Insiders. [Read Full Bio]

Rating Snapshot: