6 Best Alpha Lipoic Acid Supplements 2025 | For Antioxidant Support and Nerve Health

Best Alpha Lipoic Acid Supplements Review – Health Insiders Images

Overview

Alpha-lipoic acid (ALA) is an antioxidant produced by the body to break down carbohydrates for energy. This antioxidant is also present in foods such as red meat, potatoes, carrots, and broccoli.

While the body produces small amounts of ALA, it is present in every cell of the body where it’s required to convert food into energy.

ALA supplements help boost your natural alpha-lipoic acid supply, thus increasing their antioxidant power, ability to turn nutrients into energy, slow aging capacity, and inflammation reduction potential.

In this article, we will delve into the world of ALA supplements, their benefits, ingredients to look out for, how to pick out the best ALA supplement, and, of course, our best picks.

How We Researched and Selected the Best Alpha Lipoic Acid Supplements?

With the numerous ALA supplements present on the market, our team selected and reviewed supplements based on ingredient quality, effectiveness, scientific backing, value for money, and user reviews.

Our criteria for evaluation included:

• Ingredient quality – the ingredients present in a supplement will determine the effectiveness of the product. For this, we chose products with natural and potent ingredients.
• Effectiveness – here, we zeroed in on supplements with good ingredient blends, recommendations from specialists such as nutritionists, and user testimonials.
• Scientific backing – if science does not support the effectiveness of the ingredients used, then the product simply does not work.
• Value for money – while effective products could be a bit pricey, we still look out for a good bargain.
• User reviews – there’s no other way to know a product works than to read through the reviews of other users. Our best picks have positive feedback from previous users.

Best Alpha Lipoic Acid Supplements In 2025

WOWMD Alpha Lipoic Acid – Best Alpha Lipoic Acid Supplement

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*All the prices listed here are as they appear on their websites and are subject to change.

Our Rating

• Comfort 4.9/5
• Effectiveness 4.9/5
• Convenience 4.8/5
• Value 4.9/5

WOWMD Alpha Lipoic Acid is a powerful antioxidant supplement that enhances cellular function, supports nerve health, and helps regulate blood sugar levels. Known for its versatility, ALA works effectively in both water and fat-soluble environments, making it an excellent choice for those looking to support their overall wellness.

Key Specs

• Form: Capsule
• Type: Supplement
• Benefit: Supports nerve health, promotes balanced blood sugar, enhances antioxidant protection
• Brand: WOWMD
• Active Ingredients: Alpha Lipoic Acid (650 mg per serving)
• Dosage: Take 2 capsules daily with food
• Price: $62.10*

WOWMD Alpha Lipoic Acid Pros & Cons

Pros

• Supports healthy nerve function
• Promotes balanced blood sugar levels
• Provides powerful antioxidant protection
• Free of gluten and GMOs
• Made in the USA
• 60-day money-back guarantee on first single bottle purchase

Cons

• Requires consistent use to achieve optimal results
• Results vary based on individual factors

WOWMD Alpha Lipoic Acid Customer Reviews

Keeps nerve pain at bay
My nerve pain is way better with these. If I skip a dose, I definitely notice. – Julia R.

Boosts energy and helps with nerve health
Energy’s up and nerve discomfort is down. Feels more natural and easy to go through the day without irritation. – Lisbeth M.

Summary: WOWMD Alpha Lipoic Acid is an excellent supplement for improving nerve function and regulating blood sugar levels. Users appreciate its ability to reduce nerve discomfort and enhance overall energy levels. It’s a great addition for anyone looking to boost their health and vitality.

Natrol Alpha Lipoic Acid – Best Naturals Alpha Lipoic Acid

Our Rating

• Comfort 3.6/5
• Effectiveness 3.6/5
• Convenience 3.7/5
• Value 3.7/5

Natrol Alpha Lipoic Acid 600 mg tablets are designed to provide antioxidant support, improve glucose metabolism, and promote liver and nerve health. This supplement is made with 100% drug-free ingredients, offering a high-quality, affordable option for those looking to support their general wellness.

Key Specs

• Form: Tablet
• Type: Antioxidant Supplement
• Benefit: Antioxidant support, nerve health, glucose metabolism
• Brand: Natrol
• Active Ingredients: Alpha Lipoic Acid (600 mg), Calcium, Microcrystalline Cellulose, Magnesium Stearate
• Dosage: One tablet daily with a meal
• Price: $13.99*
• Where to Buy: Amazon

Natrol Alpha Lipoic Acid Pros & Cons

Pros

• Antioxidant support for liver and nerves
• Supports glucose metabolism
• Affordable pricing compared to similar products
• No common food allergens

Cons

• Some users report difficulty swallowing the tablet
• Price has increased recently
• May cause changes in urine odor

Natrol Alpha Lipoic Acid Customer Reviews

Mild Improvement, But Not for Everyone
I’ve been taking Natrol Alpha Lipoic Acid for a few weeks, and while there’s a slight reduction in discomfort, it hasn’t made a big difference. The tablet is also pretty large, making it hard to swallow. Not sure if I’ll repurchase. – John Mitchell

Effective, But Some Side Effects
The supplement seems to help with my energy, but I’ve noticed a strange odor in my urine. The size of the tablet also makes it difficult to take. I’m still on the fence about whether it’s worth continuing. – Lisa Carter

Summary: While Natrol Alpha Lipoic Acid is well-regarded for its antioxidant and nerve health benefits, its effectiveness may vary. Some users note discomfort with the tablet size and experience occasional side effects, like odor changes in urine.

Nutricost Alpha Lipoic Acid – Best Alpha Lipoic Acid Brand

Our Rating

• Comfort 3.7/5
• Effectiveness 3.7/5
• Convenience 3.6/5
• Value 3.7/5

Nutricost Alpha Lipoic Acid offers 600mg of potent, high-quality alpha-lipoic acid per serving. A vegan-friendly supplement designed to support antioxidant function, nerve health, and overall wellness. It’s affordable and free of gluten, soy, and GMOs.

Key Specs

• Form: Capsule
• Type: Antioxidant Supplement
• Benefit: Antioxidant support, nerve health, inflammation management
• Brand: Nutricost
• Active Ingredients: Alpha Lipoic Acid (600 mg), Di-calcium phosphate, Magnesium stearate
• Dosage: Two capsules daily with 8-12 oz of water
• Price: $24.89*
• Where to Buy: Amazon

Nutricost Alpha Lipoic Acid Pros & Cons

Pros

• Supports antioxidant activity and nerve health
• Affordable price for a high dosage
• No artificial additives or allergens

Cons

• May cause mild stomach discomfort for some users
• Packaging could be more environmentally friendly
• Not much information on ingredient sourcing

Nutricost Alpha Lipoic Acid Customer Reviews

Decent but Not a Miracle Worker
I’ve been using Nutricost Alpha Lipoic Acid for a few weeks, and while it seems to help with energy a bit, I haven’t seen major improvements in my nerve health. The capsules are easy to swallow, but I’ve had some mild stomach discomfort. – James Powell

Works, But Has Some Downsides
I noticed a slight improvement in my overall energy levels, but nothing dramatic. The price is good for the dosage, but I did experience some digestive issues after taking it. I’m unsure if I’ll keep using it. – Sara Thompson

Summary: Nutricost Alpha Lipoic Acid offers a decent dose of antioxidant support but lacks transparency in ingredient sourcing. While it’s affordable and effective for some, others report mild stomach discomfort. It may be worth considering but isn’t ideal for everyone.

GNC Alpha Lipoic Acid – Top Rated Alpha Lipoic Acid Supplements

Our Rating

• Comfort 3.5/5
• Effectiveness 3.7/5
• Convenience 3.6/5
• Value 3.6/5

GNC Alpha-Lipoic Acid 600mg supports cell energy metabolism and the regeneration of antioxidants like Vitamins C and E. This supplement helps protect cells from damage caused by free radicals, potentially improving antioxidant function and overall health.

Key Specs

• Form: Caplet
• Type: Antioxidant Supplement
• Benefit: Supports cell energy, antioxidant regeneration
• Brand: GNC
• Active Ingredients: Alpha Lipoic Acid (600 mg), Microcrystalline Cellulose, Magnesium Stearate
• Dosage: One caplet daily
• Price: $29.99*
• Where to Buy: Amazon

GNC Alpha-Lipoic Acid Pros & Cons

Pros

• Supports cell energy metabolism
• Regenerates antioxidants like Vitamin E and C
• Helps protect cells from oxidative stress
• Easy to swallow caplets

Cons

• Some users report mild side effects like nausea
• Not suitable for everyone due to possible stomach discomfort
• Packaging could be more environmentally friendly

GNC Alpha-Lipoic Acid Customer Reviews

Not Seeing Big Results
I’ve been using GNC Alpha-Lipoic Acid for a few weeks, and while it does seem to help with energy, the results aren’t as noticeable as I expected. I also had some mild nausea after taking it, which is a bit off-putting. – Peter Davis

Effective but Mild Stomach Issues
The product seems to support my energy levels, but I’ve noticed some stomach discomfort after taking it. I’m not sure if I’ll continue since the side effects are a bit bothersome, even though it’s affordable. – Emily Johnson

Summary: GNC Alpha-Lipoic Acid 600mg offers solid antioxidant support and helps with cell metabolism. However, some users experience mild stomach discomfort, and it may not be the best choice for those sensitive to supplements.

THORNE Alpha Lipoic Acid – Best Alpha Lipoic Acid for Liver Support

Our Rating

• Comfort 3.5/5
• Effectiveness 3.6/5
• Convenience 3.6/5
• Value 3.6/5

THORNE’s Alpha Lipoic Acid 300mg offers strong antioxidant support and aids in liver detoxification. This supplement helps protect cells from oxidative damage and supports healthy nerve function.

Key Specs

• Form: Capsule
• Type: Supplement
• Benefit: Liver detox, antioxidant support, nerve health
• Brand: THORNE
• Active Ingredients: Alpha Lipoic Acid (300 mg), Hypromellose, Magnesium Citrate, Silicon Dioxide
• Dosage: Take one capsule 2-3 times daily
• Price: $39.00*
• Where to Buy: Amazon

THORNE Alpha Lipoic Acid Pros & Cons

Pros

• Supports liver health and detox
• Protects cells from oxidative stress
• Helps maintain mental sharpness

Cons

• Expensive compared to other brands
• Some users experience mild digestive discomfort
• May require multiple doses per day

THORNE Alpha Lipoic Acid Customer Reviews

Effective but Pricey
THORNE Alpha Lipoic Acid seems to work well for liver support, but the cost is higher than I expected for the benefits. I’ve noticed some improvement, but I’m not convinced it’s worth the price. – David Carter

Mild Results and Some Discomfort
I’ve been using this for a few weeks, and while it might be helping a bit with energy, I’ve had some mild stomach discomfort. It’s a trusted brand, but I’m unsure if the results justify the cost. – Karen Miller

Summary: THORNE’s Alpha Lipoic Acid provides antioxidant and liver support but is on the pricier side. While effective for some, others report mild digestive issues. It is a good option for those looking for a trusted, quality supplement.

Pure Encapsulations Alpha Lipoic Acid – Best Alpha Lipoic Acid for Neuropathy

Our Rating

• Comfort 3.5/5
• Effectiveness 3.5/5
• Convenience 3.6/5
• Value 3.6/5

Pure Encapsulations Alpha Lipoic Acid 600mg offers antioxidant support, helping protect cells from oxidative damage while promoting liver health and supporting healthy nerve function. This premium supplement is made with high-quality ingredients, ensuring potency and purity.

Key Specs

• Form: Capsule
• Type: Supplement
• Benefit: Supports liver health, nerve function, and antioxidants
• Brand: Pure Encapsulations
• Active Ingredients: Alpha Lipoic Acid (600 mg), Cellulose (Vegetarian Capsule)
• Dosage: Take one capsule, 1-2 times daily with meals
• Price: $65.20*
• Where to Buy: Amazon

Pure Encapsulations Alpha Lipoic Acid Pros & Cons

Pros

• Supports liver and nerve health
• Helps protect cells from oxidative stress
• Premium, high-quality ingredients

Cons

• Expensive compared to other ALA supplements
• May cause mild digestive discomfort for some users
• Large capsules might be hard to swallow for some

Pure Encapsulations Alpha Lipoic Acid Customer Reviews

Good Quality, But Pricey
I’ve been taking this product for a while, and it seems to work fine for supporting my nerve health. However, it’s more expensive than other ALA supplements, and I’m not sure it’s worth the extra cost. – Mark Johnson

Causes Discomfort
While I’ve noticed some benefits in my energy and nerve health, I’ve also experienced mild stomach discomfort after taking it. It’s a reputable brand, but the price and discomfort make me hesitate to buy again. – Linda White

Summary: Pure Encapsulations Alpha Lipoic Acid offers solid antioxidant and nerve support but comes at a high price. While effective for some, users may experience mild digestive discomfort, and the large size of the capsules could be inconvenient.

How to Choose the Best Alpha Lipoic Acid Supplement?

Well, the formula’s quality should be the first thing to consider if your intent is to get an effective product. So, choose products with pure and quality ingredients. Besides that, check for;

• Dosage and Form – The rule of thumb when selecting an ALA supplement is to choose one that features the R-alpha lipoic acid instead of the S-alpha lipoic acid, as it is the most potent form. As for dosage, a daily dose of 600 mg to 1800 mg daily (for up to 6 months) is considered safe as per studies in the StatPearls journal.
• User Goals – since the body produces its own ALA, you may want to supplement it for various reasons. For instance, if you are looking to alleviate nerve pain caused by diabetes, you will need a high dosage of 600 mg to 1800 mg, as lower doses don’t work.
• Side Effects – like with any other supplement, you will need to understand the side effects that ALA supplements may cause, including headache, rashes, nausea, heartburn, and vomiting. Go for supplements that cause mild to zero side effects.
• Brand Reputation – always select a supplement from a reputable brand that produces quality products and considers customer satisfaction. Brands that have been on the market for longer give you a better chance to check their track record, so opt for products from these brands. Reputable brands also subject their products to third-party testing to ensure the quality and safety of their products.

Do Alpha Lipoic Acid Supplements Work?

Quality alpha lipoic acid supplements may work due to the following factors:

• Specialization – although ALA supplements can offer multiple health benefits, they tend to focus on addressing certain health issues. For instance, one may target antioxidant support, another cellular energy, and a third supplement may focus on metabolic support.
• R-LA – as we’ve mentioned earlier, the R-LA, which is the natural form of ALA, is more effective than its synthetic counterpart, S-LA. Most supplements contain the R-LA.

What Does Science Say About these Supplements?

Studies in the Journal of Biomolecules agree that ALA has numerous valuable properties.^[1] It acts as an enzymatic cofactor and is involved in glucose and lipid metabolism.

ALA also improves and helps restore the basic antioxidant systems.^[2] Other than that, ALA efficiently removes heavy metals responsible for oxidative stress from the bloodstream.

Common Ingredients Present in Best Alpha Lipoic Acid Supplements

Most ALA supplements feature ingredients such as;

Alpha Lipoic Acid

This is an organic, sulfate-based compound with potent antioxidant properties. According to the Brazilian Journal of Pharmacognosy, alpha-lipoic acid has antioxidant, anti-aging, anti-cancer, anti-inflammatory, cognitive, cardiovascular, detoxifying, and neuroprotective properties.^[3]

Tribulus Terrestris

This ingredient is known for its aphrodisiac potential. A review study in the Journal of Ethnopharmacology revealed that Tribulus terrestris plays an important role in treating erectile dysfunction and sexual desire problems.^[4]

Bitter Melon

Scientifically known as Momordica charantia, bitter melon is claimed to have positive effects on diabetes symptoms. In a 12-week clinical study published in the Journal of Food Science and Biotechnology, bitter melon extract was found to exhibit glucose-lowering effects through suppression of glucagon levels.^[5]

Coleus Forskholii

This ingredient is claimed to have the potential to lower blood pressure. Studies in the AYU journal found that Coleus forskohlii in tablet or powder form is an effective treatment for hypertension.^[6]

Cinnamon Bark Extract

A 2023 study in the Foods journal established that cinnamon bark extract contains bioactive compounds such as cinnamic acid, which maintain their antioxidant and anti-inflammatory effects even after digestion, making this ingredient effective for digestive health.^[7]

Benefits of Alpha Lipoic Acid Supplements

Some of the key benefits you get from taking the line of supplements include;

• Antioxidant support – ALA is a fat- and water-soluble antioxidant that can work in any part of the body. It helps scavenge free radicals that cause damage to cells, organs, and tissues.
• Weight loss support – ALA works to suppress the AMP-activated protein kinase (AMPK) enzyme, which plays a vital role in regulating appetite. When this enzyme is lowered, appetite reduces.
• Improved skin health – in skin care, ALA works as an anti-aging agent. Thanks to its antioxidant potential, it is able to help protect and repair the skin.
• Reduced neuropathy symptoms – diabetic neuropathy is associated with pain, tingling, and numbing sensations due to nerve damage. ALA is used to provide relief.
• Lowered blood sugar levels – ALA supplements can stimulate the body to utilize its own insulin, thereby lowering blood sugar levels.

Are Alpha Lipoic Acid Supplements Safe to Use?

Alpha lipoic acid supplements may be safe to use, but like any other supplement can cause mild side effects such as nausea, heartburn, vomiting, headache, and rashes. If you take insulin or medications to lower blood sugar, ensure to check with your doctor before taking these supplements.

Since ALA supplements also lower blood sugar, they may boost the effects of your medication and cause low blood sugar. By consulting with your healthcare provider, your blood sugar may be adjusted to accommodate your ALA supplement.

ALA supplements have not been approved by the FDA. To be on the safe side, always buy products from reputable brands that uphold quality and safety standards. Moreover, always consult your healthcare provider before starting on these supplements to help you rule out any potential contraindications.

Who Should Consider Using These Supplements?

Alpha-lipoic acid supplements are mostly used for nerve pain due to diabetes, obesity, and high cholesterol levels. For that reason, those who should consider these supplements include:

• Obese individuals – ALA helps to suppress appetite, which can help lower caloric intake, thus enhancing weight loss.
• Diabetics – ALA helps to reduce insulin resistance, thus improving glucose uptake by the body, lowering blood sugar levels. It also helps provide relief for nerve pain caused by diabetes.
• Those with high cholesterol – by improving the body’s ability to use its insulin, ALA supplements may also help to lower cholesterol and triglycerides (blood fats).
• Erectile dysfunction sufferers – ALA supplements may improve vascular function by increasing nitric oxide production, which is vital for maintaining an erection.
• Those with skin damage – ALA’s skincare potential stems from its high antioxidant potential. It may help heal damaged skin and promote wound healing.

Final Verdict

Alpha-lipoic acid is a versatile antioxidant with numerous health benefits, ranging from skincare to blood sugar regulation. Through its powerful antioxidant potential, it neutralizes free radicals that damage cells, tissues, and organs, causing chronic conditions like diabetes.

Additionally, alpha-lipoic acid has anti-inflammatory, blood sugar-regulating, insulin-sensitivity-enhancing, and weight management properties. Because of all these health benefits, ALA supplements can help with many health issues.

While ALA supplements are generally safe, it is always recommended to consult your healthcare provider before starting to use them, especially if you have underlying health conditions or are on medication.

Frequently Asked Questions