6 Best Liquid B12 Supplements: According to Health Experts

Overview

Liquid Vitamin B12 supplements offer a practical solution for ensuring your body receives its daily requirement of this vital nutrient.

They are an excellent alternative for individuals who struggle with swallowing tablets or have digestive challenges that hinder proper nutrient absorption.

Liquid B12 is particularly popular among vegans and vegetarians, as this vitamin is predominantly found in animal-based foods. These supplements are easily absorbed by the body and can deliver a quick energy boost, making them ideal for athletes and people with fast-paced lifestyles.

After thoroughly researching and evaluating various liquid B12 supplements, we’ve identified the top choices that meet these standards while offering exceptional value for their cost.

What is a Liquid B12 Supplement?

A Liquid B12 Supplement is a dietary supplement that is specifically designed to provide vitamin B12 in liquid form.

That is, unlike in the case of pills or capsules, the key approach is to have the supplement in liquid form to facilitate better absorption to achieve better outcomes.

In precise, supplementing with Liquid B12 is a better option for people who have difficulty or problem swallowing pills or who may have digestive-related conditions or that make B12 absorption inefficient.

What is B12 Deficiency?

B12 deficiency happens when your body doesn’t have enough of the vitamin, either because you’re not getting enough from food or your body can’t absorb it properly.

Common symptoms include feeling tired, weak, having numbness or tingling in your hands and feet, pale skin, a swollen tongue, trouble balancing, anemia, memory issues, or even trouble with fertility.

It can take a while for symptoms to show up since your body can store some B12 for later use.

Why is Liquid B12 Supplements Important?

Vitamin B12 is an essential nutrient required by the body for several functions, including energy metabolism, the production of red blood cells, and supporting brain health.

As a water-soluble vitamin, it plays a key role in maintaining proper nerve function and facilitating DNA synthesis. A deficiency in vitamin B12 causes anemia, neurological issues, mood disorders, depression, and cognitive challenges.

How We Researched and Selected the Liquid B12 Supplements?

All supplements were evaluated over a consistent duration, with observations recorded based on the established testing criteria. We included products from various manufacturers offering a diverse range of supplements at different price points to suit different budgets. Here is an overview of how we researched and chose the top Liquid B12 Supplements:

• Taste and Texture: Is the flavor enjoyable? Is the texture easy to consume?
• Vitamin B12 Combination: Is vitamin B12 paired with other nutrients that may enhance its effectiveness?
• Nutrient Profile: How much vitamin B12 is provided in each daily serving?
• Additives: Does the product contain any additives such as fillers, preservatives, artificial sweeteners, or colorants?
• Dietary Requirements: Does the product align with your dietary preferences – for instance, is it vegetarian, vegan, or gluten-free?
• Cost-effectiveness: How does it compare to other products in terms of price per daily dose?

Best Liquid B12 Supplements In 2025

WOWMD B-12 Complex Liquid – Best Liquid B12 Supplement Overall

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*All the prices listed here are as they appear on their websites and are subject to change.

Our Rating

• Comfort 4.9/5
• Effectiveness 4.9/5
• Convenience 4.8/5
• Value 4.9/5

WOWMD B-12 Complex Liquid is a potent blend of essential B vitamins designed to boost energy, support cognitive function, and promote overall well-being. This easy-to-take liquid formula ensures optimal absorption and is ideal for those seeking a convenient way to increase their B-vitamin intake. Perfect for general use and energy-boosting support.

Key Specs

• Form: Liquid
• Type: Supplement
• Brand: WOWMD
• Benefit: Supports energy levels, mental clarity, cognitive function, mood balance, skin health, nervous system health.
• Active Ingredients: Riboflavin, Niacin, Vitamin B6, Vitamin B12 (Methylcobalamin), Pantothenic Acid.
• Dosage: 1 ml daily or as directed by a healthcare professional.
• Price: $62.10*

Pros & Cons of WOWMD B-12 Complex Liquid

Pros

• Convenient liquid form for easy dosing
• Highly absorbable B-vitamin complex
• Supports energy, cognitive function, and overall well-being
• Made in the USA in a GMP & FDA compliant facility
• 60-day money-back guarantee on first bottle purchase

Cons

• Individual results may vary
• May take a few weeks to start noticing the effects

WOWMD B-12 Complex Liquid Customer Reviews

Very Good
I use the vitamin B drops daily and my B12 levels have been improving since I started taking them. Tastes good and so much better than pills –Paula

B12
This is one of the few vitamin B12 supplements where I can actually feel a difference right away. My energy, mood and overall well-being have significantly improved since I started taking this and I’ll definitely be reordering –Mallory

Summary: WOWMD B-12 Complex Liquid is a highly absorbable, energy-boosting supplement that supports cognitive function, mood balance, and overall well-being. Customers report improved energy and mood, and the convenient liquid form, plus a 60-day money-back guarantee, makes it a great choice.

MaryRuth Organics Vitamin B Complex – Best Rated Liquid B-12

Our Rating

• Comfort 3.8/5
• Effectiveness 3.9/5
• Convenience 3.8/5
• Value 3.8/5

MaryRuth Organics Vitamin B Complex is a liquid supplement designed to support energy metabolism, red blood cell production, and nervous system health. It contains essential B vitamins, including B3, B6, Biotin, Folate, and B12, in an easy-to-take cherry-flavored liquid form. This USDA Organic, vegan, and gluten-free formula is made for optimal absorption and overall wellness support.

Key Specs

• Form: Liquid Drops
• Type: Dietary Supplement
• Brand: MaryRuth Organics
• Benefit: Boosts energy, supports metabolism, aids brain health, promotes red blood cell formation
• Active Ingredients: Niacin (B3), Pyridoxine (B6), Biotin (B7), Folate (B9), Methylcobalamin (B12)
• Dosage: 0.5mL daily
• Price: $29.95*
• Where to Buy: Amazon

Pros & Cons of MaryRuth Organics Vitamin B Complex

Pros

• USDA Organic, vegan, and gluten-free
• Liquid form for better absorption
• Supports energy, metabolism, and cognitive function
• Clean-label, non-GMO ingredients
• Suitable for most lifestyles

Cons

• Some users may not prefer the taste
• Requires daily dosage consistency for best results

MaryRuth Organics Vitamin B Complex Customer Reviews

Works well
This Mary Ruth’s B Complex liquid vitamin is great. After taking daily for one week I started to notice more energy. The taste is good and is doable for kids and adults. I would recommend this brand and vitamin to everyone. –Teresa

Great product
Love this tincture and it has a very pleasant taste. Exactly what I needed. –Cynthia Mc

Summary: MaryRuth Organics Vitamin B Complex is a liquid supplement that supports energy, metabolism, and cognitive health. While it’s vegan and gluten-free, some users may not like the taste, and consistent daily use is needed for best results.

Nature’s Bounty B Complex – Best Liquid Vitamin B12 Supplement​

Our Rating

• Comfort 3.7/5
• Effectiveness 3.8/5
• Convenience 3.8/5
• Value 3.7/5

Nature’s Bounty B Complex with B12 is a liquid dietary supplement designed for fast absorption and easy use. This gluten-free formula helps support energy production, nervous system health, and overall well-being. The sublingual liquid form ensures quick delivery of essential B vitamins, making it ideal for those who have trouble swallowing pills.

Key Specs

• Form: Liquid
• Type: Dietary Supplement
• Brand: Nature’s Bounty
• Benefit: Supports energy metabolism, nervous system health, and overall wellness
• Active Ingredients: Vitamin B1, B2, B3, B5, B6, B7, B9, and B12
• Dosage: 1 mL under the tongue, up to 4 times daily
• Price: $7.39*
• Where to Buy: Amazon

Pros & Cons of Nature’s Bounty B Complex

Pros

• Fast-absorbing liquid formula
• Easy-to-use sublingual application
• Supports energy and metabolism
• Gluten-free and vegetarian-friendly
• Affordable price

Cons

• Some may not like the taste
• Requires multiple doses per day

Nature’s Bounty B Complex Customer Reviews

Amazing energy in mins
Easy to ingest, great taste, last me a good month plus and amazing energy in mins. Very helpful for an anemic person that suffers from heavy fatigue. Please do not switch up the formula or discontinue this product! –Sana Kibz

It Delivers as Stated
The Nature’s Bounty B-complex liquid has a pleasant cough syrup taste; and when I take it as directed, I feel an almost immediate surge of energy and well-being. I find it easier to measure 1 ml by pouring the liquid into an equivalent 1/4 tsp. measuring spoon and placing it under my tongue, rather than using the dropper. The box states it is “suitable for vegetarians.” I emailed the company; and although it isn’t indicated anywhere on the product, I was informed the B-complex liquid is certified vegan. –Amazon Customer

Summary: Nature’s Bounty B Complex is a liquid supplement that helps boost energy and metabolism. While it’s affordable and easy to use, some people don’t like the taste, and you need to take it multiple times a day for the best results.

1MD B12 – Best Vitamin B12 Softgel

Our Rating

• Comfort 3.7/5
• Effectiveness 3.6/5
• Convenience 3.6/5
• Value 3.7/5

1MD Nutrition Vegan Vitamin B12 Softgels deliver 5000mcg of methylcobalamin, the most bioavailable form of B12. This supplement supports energy production, immune health, cardiovascular function, and promotes a sense of relaxation. It’s vegan, non-GMO, and free from common allergens, ensuring you get the benefits of B12 with the highest quality ingredients.

Key Specs

• Form: Softgel
• Type: Supplement
• Brand: 1MD Nutrition
• Benefit: Boosts energy, supports immune and heart health, aids relaxation and sleep, promotes overall wellness
• Active Ingredients: Methylcobalamin (5000mcg), olive oil, sunflower Lecithin, Candelilla wax
• Dosage: 1 softgel daily with food
• Price: $24.00*
• Where to Buy: Amazon

Pros & Cons of 1MD B12

Pros

• Supports energy, heart, and immune health
• Vegan, non-GMO, allergen-free
• Maximum strength B12 formula for optimal absorption
• Promotes relaxation and better sleep quality

Cons

• Limited availability
• May cause digestive upset in sensitive individuals
• Higher price compared to other B12 supplements

1MD B12 Customer Reviews

This is the B12 I was looking for
I take it for my heart and it works very well. All good reactions and works well with my heart prescription I take. It has no flavor and is very easy to swallow. It is not very big at all. I do seem to get a lot more energy in my day. –Rebecca Houk

Not rough on my stomach
Love the components and felt the energy. – Marlene D.

Summary: 1MD B12 is a vegan, non-GMO softgel that supports energy and heart health. While it offers strong B12 absorption, some users may experience digestive issues, and it’s priced higher than other B12 supplements on the market.

Now Liquid B-12 – Best B12 Liquid Drops​

Our Rating

• Comfort 3.7/5
• Effectiveness 3.6/5
• Convenience 3.6/5
• Value 3.6/5

NOW Liquid B-12 provides a potent dose of vitamin B12, supporting energy production, nerve health, and cognitive function. This liquid form is easy to absorb and delivers immediate benefits, making it ideal for those who need quick replenishment of this essential nutrient.

Key Specs

• Form: Liquid
• Type: Supplement
• Brand: NOW Foods
• Benefit: Supports energy production, nerve health, cognitive function, and red blood cell production
• Active Ingredients: De-ionized water, glycerin, xylitol, malic acid, natural flavors, potassium sorbate, ginger root, grapefruit fiber, cinnamon bark oil
• Dosage: 1/4 teaspoon daily (approx 1 ml), hold in mouth for 30 seconds, then swallow
• Price: $9.45*
• Where to Buy: Amazon

Pros & Cons of Now Liquid B-12

Pros

• Supports energy and cognitive function
• Easy-to-use liquid formula
• Non-GMO, vegetarian, and gluten-free
• Kosher certified

Cons

• Contains preservatives like potassium sorbate
• Not suitable for people allergic to specific ingredients like ginger
• Limited flavor variety

Summary: NOW Liquid B-12 is a liquid supplement that supports energy and cognitive function. While it’s easy to use and non-GMO, it contains preservatives and may not be suitable for those allergic to ginger or specific ingredients.

Pure Encapsulations B12 Liquid – Best Liquid Vitamin B12 Supplement​

Our Rating

• Comfort 3.5/5
• Effectiveness 3.6/5
• Convenience 3.5/5
• Value 3.6/5

Pure Encapsulations B12 5,000 Liquid drops provide a highly bioavailable form of vitamin B12 (methylcobalamin) to support energy, cognitive function, nerve health, and red blood cell production. This liquid supplement is easy to take and enhances vitamin B12 absorption for quick and effective results.

Key Specs

• Form: Liquid Drops
• Type: Supplement
• Brand: Pure Encapsulations
• Benefit: Supports energy, cognitive function, nerve health, immune function, and red blood cell production
• Active Ingredients: Methylcobalamin (5000 mcg), purified water, apple juice concentrate, natural vegetable glycerin, citric acid, black currant juice, stevia leaf extract, potassium sorbate
• Dosage: 1 dropper (approx 1 ml) daily
• Price: $36.20*
• Where to Buy: Amazon

Pros & Cons of Pure Encapsulations B12 5,000 Liquid

Pros

• Supports energy, nerve, and cognitive health
• Vegan and gluten-free formula
• Easy-to-use liquid drops
• No artificial ingredients or preservatives

Cons

• Limited availability for international shipping
• May not be suitable for those with certain sensitivities to additives
• Higher price compared to other B12 supplements

Pure Encapsulations B12 5,000 Liquid Customer Reviews

High quality product that works
This arrived quickly and worked well. My blood test showed I was low in B12. After taking this for 2 months, when I retested, my levels had gone up significantly. I think the product has a pleasant taste but it is a bit expensive. –Wendy Adkinson

Great Every Day B-12 Supplement
I have been using these B-12 drops every day for the last few months. I put them in my coffee every morning, they have no taste and are not hard on the stomach. –Jennifer Morris

Summary: Pure Encapsulations B12 Liquid is a highly absorbable supplement that supports energy and cognitive health. Customers report improved B12 levels and no stomach discomfort, but it’s priced higher than other B12 options and may not suit those sensitive to additives.

How To Choose the Best Liquid B12 Supplements?

When selecting the best liquid B12 supplement, consider these essential features to ensure it meets your needs and maintains high quality.

Type of B12 – Pay attention to the type of B12 in the supplement. Common options include cyanocobalamin, methylcobalamin, and hydroxocobalamin.

Cyanocobalamin is the most stable and budget-friendly form but must be converted into methylcobalamin or hydroxocobalamin for the body to use. Methylcobalamin and hydroxocobalamin are more easily absorbed and utilized, making them preferable for many individuals.

Dosage– Consider the B12 amount provided per serving. The suggested daily intake for adults is 2.4 micrograms, though requirements may differ based on factors like age, diet, or health conditions. Look for supplements offering at least 100% of the recommended daily value and adjust your intake as needed.

Extra Components – Some liquid B12 supplements include additional vitamins, minerals, or herbal extracts. While these may provide added benefits, ensure they do not affect B12 absorption or efficiency. Choose products with straightforward, minimal ingredient lists free from unnecessary fillers or artificial additives.

Quality and Purity – Select supplements manufactured in GMP-certified facilities and verified by third-party testing for potency and cleanliness. Certifications from organizations such as NSF International or USP can provide additional assurance of quality.

Common Ingredients Present in Liquid B12 Supplements

Some key ingredients to watch out in Liquid B12 supplements include;

Vitamin B12 (Cyanocobalamin)

Cyanocobalamin is an artificial form of vitamin B12 used to treat deficiencies, though most people get enough from their diet. Research highlights that Cyanocobalamin is a man-made version of vitamin B12 commonly used to manage vitamin deficiencies.^[1]

Sorbitol

It helps preserve the quality of food products by retaining moisture, enhancing texture, serving as a crystallization inhibitor and softening agent and also supports regular bowel movements when paired with fiber. Studies indicate that sorbitol has non-cariogenic properties, making it suitable for use in nutritional products designed for individuals with diabetes.^[2]

Glycerin

Glycerin, a natural humectant, helps retain moisture, supporting hydration in the body and skin and may support gut health by relieving occasional constipation. A 2009 study has demonstrated that drinks containing glycerol can boost and sustain hydration levels and may enhance performance during endurance exercise.^[3]

What are the Benefits of Liquid B12 Supplements?

Boost B12 Levels and Address Deficiency: For individuals who struggle to maintain adequate B12 levels independently, a B12 supplement can help elevate blood concentrations of this vital nutrient and safeguard against health complications linked to B12 insufficiency.

Helps Lower Homocysteine Levels: Taking B12, alongside other nutrients like folate that regulate homocysteine, can markedly decrease homocysteine concentrations and subsequently lower the risk of diseases associated with elevated homocysteine levels.

Enhances Cognitive Health: Supplementing with vitamin B12 may aid in defending against cellular damage caused by oxidative stress, which is associated with various chronic conditions, including cognitive impairment.

Could Alleviate Symptoms of Depression: Vitamin B12 supplementation may help avert depression and relieve depressive symptoms in affected individuals.

Are Liquid B12 Supplements Safe to Use?

Liquid vitamin B12 supplements are generally regarded as safe for the majority of individuals.

Since water-soluble vitamins, such as vitamin B12, are managed by the kidneys, any surplus that your body does not require will be eliminated through urine.

This significantly reduces the likelihood of experiencing negative side effects from excessive intake.

What are the Potential Side Effects of Liquid B12 Supplements?

Although a severe allergic reaction to liquid B12 is uncommon, it’s crucial to seek immediate medical attention if you experience symptoms like a rash, itching or swelling, intense dizziness, or difficulty breathing.

This is not a comprehensive list of potential side effects, so consulting a healthcare provider is strongly advised. Some common side effects of using Liquid B12 Supplements include

• Headache
• Nausea and vomiting
• Diarrhea
• Fatigue or weakness
• Tingling sensation in hands and feet

Do Liquid B12 Supplements Work?

Liquid B12 supplements are an effective way to increase vitamin B12 levels, particularly for individuals with deficiencies or absorption issues.

Liquid supplements are absorbed directly into the bloodstream through the digestive tract, offering faster and potentially more efficient absorption than traditional tablets or capsules.

Vitamin B12 is essential for energy production, red blood cell formation, and neurological health. People with conditions such as pernicious anemia, gastrointestinal disorders, or a vegan diet may benefit greatly from supplementation.

When choosing a liquid B12 supplement, it’s important to consider the form of B12 used. Methylcobalamin, a naturally occurring and bioavailable form, is often preferred, though cyanocobalamin is also effective.

However, as with any supplement, individual results may vary. Consult with a healthcare professional to determine if liquid B12 supplements are suitable for your specific needs.

How do Liquid B12 Supplements work?

Vitamin B12 plays a vital role in your body’s production of red blood cells. When the body cannot produce a sufficient number of healthy red blood cells—often due to a vitamin B12 deficiency—it can result in a condition known as anemia.

Research indicates that oral vitamin B12 supplements are an effective and widely used method to restore normal B12 blood levels and prevent vitamin B12 deficiency anemia.^[4]

It is often suggested that vitamin B12 enhances energy levels. This vitamin aids the body in breaking down food and converting it into energy.

Additionally, a B12 deficiency can lead to anemia, which is linked to fatigue and reduced energy. Therefore, addressing a deficiency with supplementation may help increase energy levels.

Vitamin B12 also supports the breakdown of homocysteine, converting it into beneficial compounds the body requires. A 2022 analysis of eight studies showed that supplementation with B12, B6, and/or folic acid resulted in an average reduction of homocysteine levels by 31.9% in individuals with mild cognitive impairment.^[5]

When and How to Take Liquid B12 Supplements for Best Results?

If you are using an over-the-counter product for self-treatment, carefully follow all instructions on the packaging before taking it. If you have any concerns or questions, consult your pharmacist.

Take this medication orally, with or without food, as instructed by your doctor or the product label, typically once a day. To gain the most benefit, use it consistently at the same time each day.

For liquid formulations, measure your dose precisely with a proper measuring device or spoon. Avoid using a household spoon, as it may result in an inaccurate dose. Some liquid products may need to be shaken well before each use—refer to the label for specific directions.

Who Should Consider Using Liquid B12 Supplements?

Liquid B12 supplements are beneficial for individuals who struggle to maintain adequate vitamin B12 levels through diet alone. These include:

1. Vegans and Vegetarians: Since vitamin B12 is primarily found in animal-based foods, those following plant-based diets are at a higher risk of deficiency.

2. Older Adults: Aging can reduce the body’s ability to absorb B12 from food due to decreased stomach acid production.

3. People with Digestive Disorders: Conditions such as Crohn’s disease, celiac disease, or other gastrointestinal issues can impair B12 absorption.

4. Individuals with Pernicious Anemia: This autoimmune condition prevents proper absorption of B12, necessitating supplementation.

5. People with Fatigue or Low Energy: If a deficiency is contributing to low energy levels, supplementation can help restore vitality.

Who Should Stay Away from Liquid B12 Supplements?

People allergic to cobalt or vitamin B12 should avoid liquid B12 supplements. Those with Leber’s disease, a rare genetic eye condition, should also refrain from taking B12, as it may worsen symptoms.

Always consult a healthcare provider before use, especially if you have underlying health conditions or take medications.

Why Trust us?

Our experts provide well-researched, evidence-based information to help you make informed decisions about liquid vitamin B12 supplements. Our insights are drawn from credible sources, including scientific studies and expert recommendations, ensuring accuracy and reliability.

This guideline aims to address your questions, from the benefits and usage to potential concerns, offering practical guidance tailored to your needs.

Whether you’re exploring liquid B12 for energy, combating deficiency, or supporting overall health, our goal is to empower you with trusted knowledge. Always consult a healthcare professional for personalized advice.

Final Verdict

In summary, liquid vitamin B12 supplements offer a practical and efficient way to ensure your body receives the B12 it needs to maintain optimal health. It’s essential to closely follow the instructions provided on the product label and consult your healthcare provider for tailored advice.

When selecting a liquid B12 supplement, consider key aspects such as quality and strength, the type of B12 included, the recommended dosage, components, and the product’s accessibility and cost. By evaluating these elements carefully, you can find a liquid B12 supplement that best suits your needs.

Frequently Asked Questions