search
Health Insiders
Ashwagandha – Evidenced-based Information on the Promising Health Benefits, Uses, & Possible Side Effects

Ashwagandha – Evidenced-based Information on the Promising Health Benefits, Uses, & Possible Side Effects

A Scientific review of Ashwagandha- Learn more about the uses, health benefits, possible side effects and other important information here!

ashwagandha

Ashwagandha, also known as Indian ginseng, is a popular Ayurvedic herb used to treat a variety of health issues. Image via Shutterstock


Ashwagandha is a plant that is considered a small shrub with yellow flowers that are native to India and North Africa. The Ashwagandha plant is used in the form of extracts or powders from the plant’s root.

It’s also common to use its leaves to treat a variety of conditions. There have been many claims made about Ashwagandha.

This article will examine what Ashwagandha does in the body, how it is used, 5 claims about the plant, examine the research, and take a look at the possible side effects.

What is Ashwagandha?

Ashwagandha is considered a revered herb of the Indian Ayurvedic system of medicine as a tonic.

It is commonly known as “Indian Winter Cherry” or “Indian Ginseng.” It is considered one of the most important herbs of Ayurveda, which is the traditional system of medicine in India.

Ashwagandha[1] is commonly available as a churna, a finely sieved powder that can be mixed with water, clarified butter or honey. Studies have identified anticancer, antidepressant, cardioprotective, antioxidants, thyroid modulation, immunomodulation, antibacterial, neuroprotective, anti-fungal, anti-inflammatory, and hematopoietic activities.

Multiple research studies[2] have identified Ashwagandha as an herb that has many health benefits and if coupled with a healthy lifestyle it can be beneficial to your health. 

What does Ashwagandha do?

Researchers say Ashwagandha can enhance brain function and the nervous system by improving memory.

Ashwagandha is also said to improve the function of the reproductive system[3] by promoting a healthy sexual and reproductive balance.

How is Ashwagandha Used?

Ashwagandha is considered an adaptogen, which was initially defined as substances that enhance the “state of non-specific resistance” in stress, physiological conditions linked with various disorders of the neuroendocrine-immune system.

A well-known example of an adaptogen is ginseng[2], which has been shown to enhance the body’s resilience to stress. 

It is also used to provide the body with potent antioxidant properties, used to reduce blood sugar, used to reduce cortisol levels, reduce stress and anxiety, and increase muscle mass and strength.

5 Health Claims About Ashwagandha

1. Ashwagandha has claims to hold potent antioxidant properties that help protect against cellular damage caused by free radicals in our everyday environment

Ashwagandha has been shown to provide the body’s defense against certain diseases by improving the cell-mediated immunity.

It also holds potent antioxidant properties that help protect against cellular damage caused by free radicals in our everyday environment.

2. Ashwagandha can reduce blood sugar levels

In several studies, Ashwagandha has been shown to lower blood sugar levels by increasing insulin and improving insulin sensitivity in the muscle cells.

It has been shown to reduce blood sugar levels[3] in both people with diabetes and people who are considered “healthy” or not diagnosed with diabetes.

3. Ashwagandha has been shown to reduce cortisol levels

Cortisol is considered by many to be the “stress hormone.”

The following are typical examples of how the stress response operates as its intended survival mechanism[4]:

  • 1. An individual is faced with a stressor.
  • 2. A complex hormonal cascade ensues, and the adrenals secrete cortisol.
  • 3. Cortisol prepares the body for a fight-or-flight response by flooding it with glucose, supplying an immediate energy source to large muscles.
  • 4. Cortisol inhibits insulin production in an attempt to prevent glucose from being stored, favoring its immediate use.
  • 5. Cortisol narrows the arteries while the epinephrine increases heart rate, both of which force blood to pump harder and faster.
  • 6. The individual addresses and resolves the situation.
  • 7. Hormone levels return to normal.

Now that we understand what cortisol does, we can understand why Ashwagandha may be beneficial to lower cortisol levels to in turn lessen the negative side effects that can occur if we have increased levels of cortisol.

4. Ashwagandha may help reduce stress and anxiety

Animal controlled studies using rats have reported that Ashwagandha has the ability to block the stress pathways in the brain of rats by regulating chemical signaling in the nervous system.

However, human studies have shown that symptoms of stress and anxiety can be reduced[5].

5. Ashwagandha may increase muscle mass and strength

Research has shown that Ashwagandha may improve body composition and increase strength. Some studies have determined a safe and effective upper limit.

One study suggested that men who took 750 mg -1,250 mg of pulverized Ashwagandha root per day gained muscle strength after 30 days.

The exercise regimen[6], if any, was unclear for each participant. For this reason, the relevance of the results is unclear.

The limited research available suggests that Ashwagandha may help increase muscle mass and strength. 

What does the research tell us?

While there is a substantial amount of evidence that supports certain claims on the health benefits of Ashwagandha, more evidence and clarification within certain studies are needed.

It is considered an ancient medical herb with multiple health benefits. It is shown to hold potent antioxidant properties, reduce blood sugar levels, reduce cortisol levels, reduce stress and anxiety, and increase muscle mass and strength. 

Ashwagandha supplementation could be considered a safe, easy and effective way to help improve your health and quality of life along with other healthy lifestyle factors. It is noted, that there can always be a drug or herb – nutrient interaction that can have an adverse effect on your health.

Also, not everyone reacts to medicinal herbs in the same manner.

It is advised, that people who are using any form of supplementation to seek guidance and recommendations from a medical professional (doctor) prior to use. 

More Information

It is recommended that if you are experiencing any of the following symptoms or side effects to contact your doctor. 

According to case reports, here is a list of other symptoms that may occur:

  • Mild to moderate and transient: drowsiness, upper GI discomfort, abdominal bloating, or loose stools.
  • Nausea, headache, stomach irritation: occurred in one study and was managed with other standard therapies
  • Overactive thyroid
  • Burning, itching, and discoloration of the skin
  • Irregular heartbeat, dizziness
  • Elevation of liver enzymes, skin rash, fatigue, fever, edema, and diarrhea

According to the Memorial Sloan Kettering Cancer Center, it provides information to patients and loved ones about herbs, botanicals, and other products.

According to the clinical summary, laboratory studies said Ashwagandha reduced the growth of breast, central nervous system, colon, and lung cancer without affecting normal cells, but was not effective against drug-resistant cancer stem cells[7].

Bottom Line

Ashwagandha can be an effective way to better your health. It is important to understand why you are taking this herb and the side effects it may have on your health.

Taking Ashwagandha could be an excellent approach to support an already diagnosed condition in conjunction with leading a healthy lifestyle.

Feedback:

References

1. An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med. 2011; 8(5 Suppl): 208–213. Published online 2011 Jul 3. doi: 10.4314/ajtcam.v8i5S.9
2. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity. Pharmaceuticals (Basel). 2010 Jan; 3(1): 188–224. Published online 2010 Jan 19. doi: 10.3390/ph3010188
3. Phytochemistry. 2015 Aug;116:283-289. doi: 10.1016/j.phytochem.2015.02.029. Epub 2015 Mar 18.
4. Aronson D. Cortisol — Its Role in Stress, Inflammation, and Indications for Diet Therapy. Today’s Dietitian. Vol. 11 No. 11 p. 38.
5. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012 Jul;34(3):255-62. doi: 10.4103/0253-7176.106022.
6. Raut AA, Rege NN, Tadvi FM, Solanki PV. Exploratory study to evaluate tolerability, safety, and activity of Ashwagandha in healthy volunteers. J Ayurveda Integr Med. 2012 Jul;3(3):111-4. doi: 10.4103/0975-9476.100168
7. Ashwagandha. For patients and caregivers. Memorial Sloan Kettering Cancer Center. https://www.mskcc.org/cancer-care/integrative-medicine/herbs/ashwagandha#msk_professional. Updated June 29th, 2019.
Author
instagram instagram

Anita Jalloh, MS

Anita is a nutrition expert with a Master's in Nutrition and Dietetics. Founder and CEO of Comprehensive Medical Nutrition Solutions, a...

READ THIS NEXT

View All
X

How helpful was it?

icon This article changed my life! icon This article was informative. icon I have a medical question. icon Ask a Question
X

How helpful was it?

icon This article changed my life! Change
Your Rating
Note: Health Insiders isn't a healthcare provider. We can't respond to health questions or give you medical advice.
Your Privacy is important to us.
X

How helpful was it?

icon This article was informative. Change
Your Rating
Note: Health Insiders isn't a healthcare provider. We can't respond to health questions or give you medical advice.
Your Privacy is important to us.
X
icon I have a medical question. Change

We’re unable to offer personal health advice, but we’ve partnered with JustAnswer who offers on-demand doctors to answer your medical questions 24/7. Talk online now with a doctor and get fast 1-on-1 answers from the comfort of your couch.

just answer logo
ASK A DOCTOR NOW

If you’re facing a medical emergency, call your local emergency services immediately, or visit the nearest emergency room or urgent care center.

X

How can we improve it?

icon This article contains incorrect information. icon This article doesn’t have the information I’m looking for. icon I have a medical question. icon Ask a Question
X

How can we improve it?

icon This article contains incorrect information. Change
Your Rating
Note: Health Insiders isn't a healthcare provider. We can't respond to health questions or give you medical advice.
Your Privacy is important to us.
X

How can we improve it?

icon This article doesn’t have the information I’m looking for. Change
Your Rating
Note: Health Insiders isn't a healthcare provider. We can't respond to health questions or give you medical advice.
Your Privacy is important to us.
X
icon I have a medical question. Change

We’re unable to offer personal health advice, but we’ve partnered with JustAnswer who offers on-demand doctors to answer your medical questions 24/7. Talk online now with a doctor and get fast 1-on-1 answers from the comfort of your couch.

just answer logo
ASK A DOCTOR NOW

If you’re facing a medical emergency, call your local emergency services immediately, or visit the nearest emergency room or urgent care center.

x

Have a Question? Please Tell Us What We Are Missing Here!

Find answers in product info, Q&As, reviews
Submit Your Privacy is important to us.
X

Healthinsiders.com is intended to be used for educational and information purposes only. All Health Insiders content is medically reviewed and fact-checked by a board of medical experts to ensure accuracy.

In keeping with our strict quality guidelines, we only cite academic research institutions, medical authorities, or peer-reviewed studies in our content. You will be able to find links to these sources by clicking the numbers in parentheses (1, 2, etc.) that appear throughout our content.

Medical Disclaimer: This product/supplement review is not intended to provide diagnosis, treatment, or medical advice. Please consult with a physician or other healthcare professional regarding any medical or health-related diagnosis or treatment options.

Health Insiders does not assume liability for any actions undertaken after visiting these pages and does not assume liability if one misuses supplements. Healthinsiders.com and its Editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of Healthinsiders.com.

We invite you to contact us regarding any inaccuracies, information that is out of date, or any otherwise dubious content that you find on our sites via our feedback form.